Seladelpar Lysine dihydrate is a potent PPAR-δ agonist with an EC50 value of 2 nM. This compound exhibits significant specificity, demonstrating over 750-fold selectivity for PPAR-δ compared to PPARα and over 2500-fold selectivity relative to PPARγ. Research applications include the investigation of primary biliary cholangitis and the modulation of metabolic conditions, including the normalization of hyperglycemia, hyperinsulinemia, serum lipids, and cholesterol levels. Additionally, Seladelpar Lysine dihydrate has been shown to ameliorate nonalcoholic steatohepatitis in mouse models.
Seladelpar Lysine dihydrate is a potent PPAR-δ agonist with an EC50 value of 2 nM. This compound exhibits significant specificity, demonstrating over 750-fold selectivity for PPAR-δ compared to PPARα and over 2500-fold selectivity relative to PPARγ. Research applications include the investigation of primary biliary cholangitis and the modulation of metabolic conditions, including the normalization of hyperglycemia, hyperinsulinemia, serum lipids, and cholesterol levels. Additionally, Seladelpar Lysine dihydrate has been shown to ameliorate nonalcoholic steatohepatitis in mouse models.
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