Fig. 1 · Structure
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Setmelanotide monoacetate
MC4R Agonist
Setmelanotide monoacetate is a potent agonist of the melanocortin 4 receptor (MC4R), exhibiting EC50 values of 0.27 nM in human and 0.28 nM in rat models. This compound plays a crucial role in regulating appetite and energy homeostasis, making it valuable for research applications related to obesity and metabolic disorders. Its specificity for MC4R also makes it a useful tool for studying melanocortin signaling pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Agonist |
| CAS Number | 2759937-80-7 |
| Applications | MC4R Agonist |
| Formula | C51H72N18O11S2 |
| Molecular Weight | 1177.36 |
| Synonyms | RM-493 monoacetate; BIM-22493 monoacetate; IRC-022493 monoacetate |
| SMILES | O=C([C@@H](NC([C@H](NC([C@@H](NC([C@H](NC([C@H](CSSC[C@H](NC1=O)C(N)=O)NC([C@@H](NC(C)=O)CCCNC(N)=N)=O)=O)C)=O)CC2=CN=CN2)=O)CC3=CC=CC=C3)=O)CCCNC(N)=N)N[C@H]1CC4=CNC5=CC=CC=C45.CC(O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.