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Setmelanotide monoacetate

Catalog No.: A61658
MC4R Agonist
Setmelanotide monoacetate is a potent agonist of the melanocortin 4 receptor (MC4R), exhibiting EC50 values of 0.27 nM in human and 0.28 nM in rat models. This compound plays a crucial role in regulating appetite and energy homeostasis, making it valuable for research applications related to obesity and metabolic disorders. Its specificity for MC4R also makes it a useful tool for studying melanocortin signaling pathways.
Setmelanotide monoacetate 2759937-80-7 MC4R Agonist
Grouped product items
Size Price Stock Qty
1mg
$105.00
In stock
5mg
$250.00
In stock
10mg
$380.00
In stock
25mg
$630.00
In stock
50mg
$860.00
In stock
100mg
$1,135.00
In stock
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionSetmelanotide monoacetate is a potent agonist of the melanocortin 4 receptor (MC4R), exhibiting EC50 values of 0.27 nM in human and 0.28 nM in rat models. This compound plays a crucial role in regulating appetite and energy homeostasis, making it valuable for research applications related to obesity and metabolic disorders. Its specificity for MC4R also makes it a useful tool for studying melanocortin signaling pathways.
Product Information
Catalog NumA61658
FormulaC51H72N18O11S2
Molecular Weight1177.36
CAS Number2759937-80-7
SequenceAc-Arg-Cys-{d-Ala}-His-{d-Phe}-Arg-Trp-Cys-NH2 (Disulfide bridge:Cys2-Cys8)
Sequence shorteningAc-RC-{d-Ala}-H-{d-Phe}-RWC-NH2 (Disulfide bridge:Cys2-Cys8)
SMILESO=C([C@@H](NC([C@H](NC([C@@H](NC([C@H](NC([C@H](CSSC[C@H](NC1=O)C(N)=O)NC([C@@H](NC(C)=O)CCCNC(N)=N)=O)=O)C)=O)CC2=CN=CN2)=O)CC3=CC=CC=C3)=O)CCCNC(N)=N)N[C@H]1CC4=CNC5=CC=CC=C45.CC(O)=O
SynonymsRM-493 monoacetate; BIM-22493 monoacetate; IRC-022493 monoacetate
Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C1V1 = C2V2

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GPCR/G Protein > Melanocortin Receptor