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SGI 1027


DNMT inhibitor

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Catalog No. A14120

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
SGI 1027 10mg A14120-10

Regular Price: $90.00

Special Price: $81.00

SGI 1027 25mg A14120-25

Regular Price: $180.00

Special Price: $162.00

SGI 1027 50mg A14120-50

Regular Price: $310.00

Special Price: $279.00

SGI 1027 10mM * 1mL in DMSO A14120-10mM-D

Regular Price: $110.00

Special Price: $99.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

SGI 1027 is a DNMT inhibitor with IC50 of 6, 8, 7.5 uM for DNMT1, DNMT3A, and DNMT3B, respectively.

SGI 1027

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Chemical Information

Catalog Num A14120
Actions Inhibitor
M. Wt 461.52
Formula C27H23N7O
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1020149-73-8
Synonyms SGI-1027, SGI1027

Biological Activity

SGI 1027 is a DNMT inhibitor with IC50 of 6, 8, 7.5 uM for DNMT1, DNMT3A, and DNMT3B, respectively.
DNMT1 (Cell-free assay) DNMT3B (Cell-free assay) DNMT3A (Cell-free assay)
6 μM7.5 μM8 μM


Solubility (25°C)* In vitro DMSO 92 mg/mL (199.34 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.67 mL 108.34 mL 216.68mL
0.5 mM 4.33 mL 21.67 mL 43.34 mL
1 mM 2.17 mL 10.83 mL 21.67 mL
5 mM 0.43 mL 2.17 mL 4.33 mL

*The above data is based on the productmolecular weight 461.52. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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