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SHA 68

Catalog No.: A62175
Non-peptide NPSR Antagonist
SHA 68 is a potent and selective non-peptide antagonist of the neuropeptide S receptor (NPSR), demonstrating IC50 values of 22.0 nM for NPSR Asn107 and 23.8 nM for NPSR Ile107. This compound exhibits limited blood-brain barrier penetration, making it suitable for research on peripheral applications and neuralgia. SHA 68 is valuable for studying the physiological roles of neuropeptide S and its potential implications in pain modulation and neurobiology.
SHA 68 847553-89-3 Non-peptide NPSR Antagonist
Grouped product items
Size Price Stock Qty
1mg
$30.00
In stock
5mg
$70.00
In stock
10mg
$115.00
In stock
25mg
$230.00
In stock
50mg
$360.00
In stock
100mg
$560.00
In stock
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Research use only. We do not sell to patients.
Data Sheet SDS Compound Handling Instructions

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionSHA 68 is a potent and selective non-peptide antagonist of the neuropeptide S receptor (NPSR), demonstrating IC50 values of 22.0 nM for NPSR Asn107 and 23.8 nM for NPSR Ile107. This compound exhibits limited blood-brain barrier penetration, making it suitable for research on peripheral applications and neuralgia. SHA 68 is valuable for studying the physiological roles of neuropeptide S and its potential implications in pain modulation and neurobiology.
Product Information
Catalog NumA62175
FormulaC26H24FN3O3
Molecular Weight445.49
CAS Number847553-89-3
SMILESO=C(N1CC2N(C(OC2(C3=CC=CC=C3)C4=CC=CC=C4)=O)CC1)NCC5=CC=C(F)C=C5
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