SHR0687 is a selective tetrapeptide kappa opioid receptor (KOR) agonist, exhibiting an EC50 of 0.53 pM. This compound demonstrates high potency and selectivity for KOR over mu opioid receptors (MOR) and delta opioid receptors (DOR), with minimal penetration of the blood-brain barrier. SHR0687 selectively activates KOR, which may enable the modulation of neurological pathways while minimizing central nervous system side effects. It is suitable for research applications focused on pain modulation and the exploration of KOR-related mechanisms.
SHR0687 is a selective tetrapeptide kappa opioid receptor (KOR) agonist, exhibiting an EC50 of 0.53 pM. This compound demonstrates high potency and selectivity for KOR over mu opioid receptors (MOR) and delta opioid receptors (DOR), with minimal penetration of the blood-brain barrier. SHR0687 selectively activates KOR, which may enable the modulation of neurological pathways while minimizing central nervous system side effects. It is suitable for research applications focused on pain modulation and the exploration of KOR-related mechanisms.
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