SHR902275 is a selective and potent b/cRAF inhibitor, specifically designed to target RAS mutant cancers. It demonstrates impressive inhibitory activity with IC50 values of 1.6 nM for cRAF, 10 nM for bRAFwt, and 5.7 nM for the bRAFV600E mutation. In cellular assays, SHR902275 effectively inhibits growth with GI50 values of 1.5 nM and 0.17 nM for H358, as well as 0.4 nM and 0.32 nM for A375 and Calu6, and SK-MEL2 cells, respectively. This compound holds potential for research applications focused on targeted cancer therapies and understanding RAF signaling pathways.
SHR902275 is a selective and potent b/cRAF inhibitor, specifically designed to target RAS mutant cancers. It demonstrates impressive inhibitory activity with IC50 values of 1.6 nM for cRAF, 10 nM for bRAFwt, and 5.7 nM for the bRAFV600E mutation. In cellular assays, SHR902275 effectively inhibits growth with GI50 values of 1.5 nM and 0.17 nM for H358, as well as 0.4 nM and 0.32 nM for A375 and Calu6, and SK-MEL2 cells, respectively. This compound holds potential for research applications focused on targeted cancer therapies and understanding RAF signaling pathways.
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