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- Yang Li, .et al. SIRT2 Promotes the Migration and Invasion of Gastric Cancer through RAS/ERK/JNK/MMP-9 Pathway by Increasing PEPCK1-Related Metabolism, Neoplasia, 2018, Jul; 20(7): 745-756 PMID: 29925042
Biological Activity
SirReal2 is a potent and selective Sirt2 inhibitor with IC50 of 140 nM.
Targets
| SIRT2 | ||||
| 140 nM |
| In vitro | DMSO | Warmed: 71 mg/mL (168.82 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 23.78 mL | 118.89 mL | 237.78 mL |
| 0.5 mM | 4.76 mL | 23.78 mL | 47.56 mL |
| 1 mM | 2.38 mL | 11.89 mL | 23.78 mL |
| 5 mM | 0.48 mL | 2.38 mL | 4.76 mL |
*The above data is based on the productmolecular weight 420.55. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A15902 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 709002-46-0 |
| Formula | C22H20N4OS2 |
| M. Wt | 420.55 |
| Purity | >98% |
| SMILES | CC1=NC(SCC(NC2=NC=C(CC3=C(C=CC=C4)C4=CC=C3)S2)=O)=NC(C)=C1 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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