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SRT2104 (GSK2245840)

Catalog No.: A14188

SIRT1 activator

SRT2104 (GSK2245840)

SRT2104 (GSK2245840) Chemical Structure

CAS NO. 1093403-33-8

SRT2104 (GSK2245840) is a selective SIRT1 activator involved in the regulation of energy homeostasis. Phase 2.

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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Eleni Pitsillou, .et al. Interaction of small molecules with the SARS-CoV-2 main protease in silico and in vitro validation of potential lead compounds using an enzyme-linked immunosorbent assay, Comput Biol Chem, 2020, 89: 107408 PMID: 33137690
  • Liu X, .et al. Exploring the role of orexin B-sirtuin 1-HIF-1α in diabetes-mellitus induced vascular endothelial dysfunction and associated myocardial injury in rats, Life Sci, 2019, Nov 9:117041 PMID: 31715188

Biological Activity

SRT2104 (GSK2245840) is a selective SIRT1 activator involved in the regulation of energy homeostasis. Phase 2.
In vitro DMSO Warmed: 5 mg/mL (9.68 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.36 mL 96.78 mL 193.56 mL
0.5 mM 3.87 mL 19.36 mL 38.71 mL
1 mM 1.94 mL 9.68 mL 19.36 mL
5 mM 0.39 mL 1.94 mL 3.87 mL

*The above data is based on the productmolecular weight 516.64. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A14188
Actions Activator
CAS No. 1093403-33-8
Formula C26H24N6O2S2
M. Wt 516.64
Purity >98%

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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