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|Storage||at -20°C 3 years Powder|
|Chemical Name||(R)-3-amino-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one phosphate monohydrate|
|Sitagliptin phosphate is an anti-diabetic (antihyperglycemic) drug of the dipeptidyl peptidase-4 (DPP-4) class. Inhibition of the enzyme DPP-4 is thought to increase Glucagon-like peptide-1 (GLP-1) which inhibits glucagon release , stimulates the insulin release and lowers blood glucose.|
|Solubility (25°C) *||In vitro||DMSO||100 mg/mL (191.08 mM)|
|Water||41 mg/mL (78.34 mM)|
|Ethanol||<1 mg/mL (<1 mM)|
|In vivo||Saline||30 mg/mL|
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Preparing Stock Solutions
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.1 mM||19.11 mL||95.55 mL||191.09mL|
|0.5 mM||3.82 mL||19.11 mL||38.22 mL|
|1 mM||1.91 mL||9.55 mL||19.11 mL|
|5 mM||0.38 mL||1.91 mL||3.82 mL|
*The above data is based on the productmolecular weight 523.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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