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DDP-4 inhibitor

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Catalog No. A14377

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
Sitagliptin 25mg A14377-25
Sitagliptin 50mg A14377-50
Sitagliptin 100mg A14377-100
Sitagliptin 10mM * 1mL in DMSO A14377-10mM-D

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

Sitagliptin is an oral antihyperglycemic (anti-diabetic drug) of the dipeptidyl peptidase-4 (DPP-4) inhibitor class.


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Publications citing Adooq Products
Sitagliptin Citations (2)
  • Hae Jin Kim, .et al. Potentiation of endothelium-dependent vasorelaxation of mesenteric arteries from spontaneously hypertensive rats by gemigliptin, a dipeptidyl peptidase-4 inhibitor class of anti-diabetic drug, Korean J Physiol Pharmacol, 2018, Nov; 22(6): 713-719 PMID: 30402032
  • Chintan N. Koyani, .et al. Saxagliptin but Not Sitagliptin Inhibits CaMKII and PKC via DPP9 Inhibition in Cardiomyocytes, Front Physiol, 2018, 9: 1622 PMID: 30487758

Chemical Information

Catalog Num A14377
Actions Inhibitor
M. Wt 407.31
Formula C16H15F6N5O
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 486460-32-6
Synonyms MK-0431, MK 0431, MK0431
SMILES C1CN2C(=NN=C2C(F)(F)F)CN1C(=O)C[[email protected]@H](CC3=CC(=C(C=C3F)F)F)N

Biological Activity

Sitagliptin is an oral antihyperglycemic (anti-diabetic drug) of the dipeptidyl peptidase-4 (DPP-4) inhibitor class.


Solubility (25°C) * In vitro DMSO 100 mg/mL (191.08 mM)
Water 41 mg/mL (78.34 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo Saline 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 24.55 mL 122.76 mL 245.51mL
0.5 mM 4.91 mL 24.55 mL 49.1 mL
1 mM 2.46 mL 12.28 mL 24.55 mL
5 mM 0.49 mL 2.46 mL 4.91 mL

*The above data is based on the productmolecular weight 407.31. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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