Sitagliptin

Catalog No.: A14377

DDP-4 inhibitor

Sitagliptin

Sitagliptin Chemical Structure

CAS NO. 486460-32-6

Sitagliptin is an oral antihyperglycemic (anti-diabetic drug) of the dipeptidyl peptidase-4 (DPP-4) inhibitor class.

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100 mg
$55.00
500 mg
$160.00
10mM * 1mL in DMSO
$50.00
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  • Hae Jin Kim, .et al. Potentiation of endothelium-dependent vasorelaxation of mesenteric arteries from spontaneously hypertensive rats by gemigliptin, a dipeptidyl peptidase-4 inhibitor class of anti-diabetic drug, Korean J Physiol Pharmacol, 2018, Nov; 22(6): 713-719 PMID: 30402032
  • Chintan N. Koyani, .et al. Saxagliptin but Not Sitagliptin Inhibits CaMKII and PKC via DPP9 Inhibition in Cardiomyocytes, Front Physiol, 2018, 9: 1622 PMID: 30487758

Biological Activity

Sitagliptin is an oral antihyperglycemic (anti-diabetic drug) of the dipeptidyl peptidase-4 (DPP-4) inhibitor class.
In vitro DMSO 79 mg/mL (193.95 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 24.55 mL 122.76 mL 245.51 mL
0.5 mM 4.91 mL 24.55 mL 49.1 mL
1 mM 2.46 mL 12.28 mL 24.55 mL
5 mM 0.49 mL 2.46 mL 4.91 mL

*The above data is based on the productmolecular weight 407.31. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A14377
Actions Inhibitor
CAS No. 486460-32-6
Formula C16H15F6N5O
M. Wt 407.31
Purity >98%
Synonyms MK-0431, MK 0431, MK0431
SMILES C1CN2C(=NN=C2C(F)(F)F)CN1C(=O)C[[email protected]@H](CC3=CC(=C(C=C3F)F)F)N
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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