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SL-327 is a selective inhibitor of MEK1 and MEK2 (IC50 values are 0.18 and 0.22 μM respectively); blocks hippocampal LTP in vitro. Brain penetrant in vivo, blocking fear conditioning and learning in rats, and producing neuroprotection in mice, following systemic administration.
Targets
| Target | Value |
|---|---|
| MEK1 | IC50: 0.18μM |
| MEK2 | IC50: 0.22μM |
| AP-1 | IC50: 2.03μM |
| PKC | IC50: >10μM |
| MKK3/p38MAPK | IC50: 21μM |
| ERK1 | IC50: >50μM |
| MKK4 | IC50: >100μM |
| JNK | IC50: >100μM |
| In vitro | DMSO | 4 mg/mL (11.92 mM) | |
| Water | <1 mg/mL (<1 mM) | ||
| Ethanol | 7 mg/mL (20.87 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 29.82 mL | 149.08 mL | 298.15 mL |
| 0.5 mM | 5.96 mL | 29.82 mL | 59.63 mL |
| 1 mM | 2.98 mL | 14.91 mL | 29.82 mL |
| 5 mM | 0.6 mL | 2.98 mL | 5.96 mL |
*The above data is based on the productmolecular weight 335.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Technical Details
| Catalog Num | A14137 |
|---|---|
| Actions | Inhibitor |
| M. Wt | 335.4 |
| Formula | C16H12F3N3S |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 305350-87-2 |
| Synonyms | SL 327, SL327 |
| SMILES | C1=CC=C(C(=C1)C(=C(N)SC2=CC=C(C=C2)N)C#N)C(F)(F)F |
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