Total item
Cart Subtotal
$0.00 Biological Activity
SL-327 is a selective inhibitor of MEK1 and MEK2 (IC50 values are 0.18 and 0.22 μM respectively); blocks hippocampal LTP in vitro. Brain penetrant in vivo, blocking fear conditioning and learning in rats, and producing neuroprotection in mice, following systemic administration.
Targets
| Target | Value |
|---|---|
| MEK1 | IC50: 0.18μM |
| MEK2 | IC50: 0.22μM |
| AP-1 | IC50: 2.03μM |
| PKC | IC50: >10μM |
| MKK3/p38MAPK | IC50: 21μM |
| ERK1 | IC50: >50μM |
| MKK4 | IC50: >100μM |
| JNK | IC50: >100μM |
| In vitro | DMSO | 4 mg/mL (11.92 mM) | |
| Water | <1 mg/mL (<1 mM) | ||
| Ethanol | 7 mg/mL (20.87 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 29.82 mL | 149.08 mL | 298.15 mL |
| 0.5 mM | 5.96 mL | 29.82 mL | 59.63 mL |
| 1 mM | 2.98 mL | 14.91 mL | 29.82 mL |
| 5 mM | 0.6 mL | 2.98 mL | 5.96 mL |
*The above data is based on the productmolecular weight 335.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A14137 |
|---|---|
| Actions | Inhibitor |
| M. Wt | 335.4 |
| Formula | C16H12F3N3S |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 305350-87-2 |
| Synonyms | SL 327, SL327 |
| SMILES | C1=CC=C(C(=C1)C(=C(N)SC2=CC=C(C=C2)N)C#N)C(F)(F)F |
Product Tags
Product Questions
Product Questions
No Questions
You may also be interested in the following product(s)
PD0325901
PD0325901 is MEK inhibitor and non-competitive with ATP, Kiapp of 1 nM against activated MEK1 and MEK2.
MEK162 (ARRY-438162, Binimetinib)
MEK162 (ARRY-438162) is a potent, selective, ATP uncompetitive inhibitor of MEK1/2.
GDC-0623
GDC-0623 is a potent and ATP-uncompetitive MEK1 inhibitor with Ki of 0.13 nM. Phase 1.
BIX 02189
BIX 02189 is a selective dual MEK5 and ERK5 (or BMK1) kinase inhibitor, with IC50 values of 1.5, 59, 580 and >6200 nM for MEK5, ERK5, TGFbR1…
RO5126766 (CH5126766)
RO5126766, also known as CH5126766, is a protein kinase inhibitor specific for the Raf and MEK mitogen-activated protein kinases (MAPKs) wi…
Chlortetracycline Hydrochloride
Chlortetracycline hydrochloride is a specific and potent calcium ionophore antibiotic.
BI-847325
BI-847325 is an orally bioavailable, and selective dual MEK/Aurora kinase inhibitor with IC50 of 3 nM, 25 nM, 15 nM, 25 nM, and 4 nM for Xen…
AS703026 (Pimasertib)
AS703026 is a novel, selective, orally bioavailable MEK1/2 inhibitor that inhibits growth and survival of MM cells and cytokine-induced oste…
Keywords:buy SL-327 | SL-327 Supplier | purchase | cost | manufacturer | order | distributor | buy 305350-87-2| 305350-87-2 Supplier | purchase 305350-87-2 | 305350-87-2 cost | 305350-87-2 manufacturer | order 305350-87-2 | 305350-87-2 distributor
Adooq Quality Guarantee
We promise all products perform as described.