SMK-17 is a selective, non-ATP-competitive inhibitor of MEK1 and MEK2, exhibiting IC50 values of 62 nM and 56 nM, respectively. By binding to the allosteric pocket of MEK1/2, SMK-17 effectively modulates the MAPK signaling pathway. This compound demonstrates significant biological activity by inducing apoptosis in tumor cell lines with β-catenin mutations, making it a valuable tool for cancer research and therapeutic investigations targeting these mutations.
SMK-17 is a selective, non-ATP-competitive inhibitor of MEK1 and MEK2, exhibiting IC50 values of 62 nM and 56 nM, respectively. By binding to the allosteric pocket of MEK1/2, SMK-17 effectively modulates the MAPK signaling pathway. This compound demonstrates significant biological activity by inducing apoptosis in tumor cell lines with β-catenin mutations, making it a valuable tool for cancer research and therapeutic investigations targeting these mutations.
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