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SMW139

Catalog No.: A36152
P2X7R Selective Allosteric Antagonist
SMW139 is a selective allosteric antagonist of the P2X7 receptor, demonstrating a Ki value of 32 nM for human P2X7R. This compound exhibits potential in modulating inflammatory responses and has applications in research related to Alzheimer's disease and multiple sclerosis. With a half-life of 47 minutes in rat liver microsomes, SMW139 serves as a valuable tool for investigating the therapeutic effects on P2X7R-mediated pathways.
SMW139 2133010-38-3 P2X7R Selective Allosteric Antagonist
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionSMW139 is a selective allosteric antagonist of the P2X7 receptor, demonstrating a Ki value of 32 nM for human P2X7R. This compound exhibits potential in modulating inflammatory responses and has applications in research related to Alzheimer's disease and multiple sclerosis. With a half-life of 47 minutes in rat liver microsomes, SMW139 serves as a valuable tool for investigating the therapeutic effects on P2X7R-mediated pathways.
Product Information
Catalog NumA36152
FormulaC19H21ClF3NO2
Molecular Weight387.82
CAS Number2133010-38-3
SMILESO=C(C1=CC(OC)=CC=C1Cl)NCC(C[C@]2(C3)F)(C[C@@]43F)C[C@](C4)(C2)F
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Neuronal Signaling > P2X Receptor