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JNK inhibitor

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Catalog No. A10860

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
SP600125 10mg A10860-10

Regular Price: €38.00

Special Price: €34.20

SP600125 25mg A10860-25

Regular Price: €47.50

Special Price: €42.75

SP600125 50mg A10860-50

Regular Price: €61.75

Special Price: €55.58

SP600125 200mg A10860-200

Regular Price: €123.50

Special Price: €111.15

SP600125 10mM * 1mL in DMSO A10860-10mM-D

Regular Price: €64.60

Special Price: €58.14

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

SP600125 is a JNK inhibitor with IC50=40 nM for JNK-1 and JNK-2 and 90 nM for JNK-3.


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Publications citing Adooq Products
SP600125 Citations (4)
  • Byungki Jang, .et al. The Peptidylarginine Deiminase Inhibitor Cl-Amidine Suppresses Inducible Nitric Oxide Synthase Expression in Dendritic Cells, Int J Mol Sci, 2017, Nov; 18(11): 2258 PMID: 29077055
  • Yuki Haga, .et al. Overexpression of c-Jun contributes to sorafenib resistance in human hepatoma cell lines, PLoS One, 2017, 12(3): e0174153 PMID: 28323861
  • Jia-Shiuan Tsai, .et al. Cadmium Activates Multiple Signaling Pathways That Coordinately Stimulate Akt Activity to Enhance c-Myc mRNA Stability, PLoS One, 2016, 11(1): e0147011 PMID: 26751215
  • Choe YJ, .et al. Nutlin-3 induces HO-1 expression by activating JNK in a transcription-independent manner of p53., Int J Oncol., 2014, 44(3):761-8. PMID: 24366007

Chemical Information

Catalog Num A10860
Actions Inhibitor
M. Wt 220.2
Formula C14H8N2O
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 129-56-6
Synonyms N/A

Biological Activity

SP600125 is a JNK inhibitor with IC50=40 nM for JNK-1 and JNK-2 and 90 nM for JNK-3.
Target Value
JNK1IC50: 40nM
JNK2IC50: 40nM
AuroraAIC50: 60nM
TrkAIC50: 70nM
JNK3IC50: 90nM
FLT3IC50: 90nM
MKK4IC50: 0.4μM
MKK6IC50: 1.0μM
PKBIC50: 1.0μM
MKK3IC50: 1.5μM
PKCαIC50: 1.5μM
p56LCKIC50: 4.3μM
MKK7IC50: 5.1μM
MEKK1IC50: >10μM
ERK2IC50: >10μM
p38βIC50: >10μM
PKAIC50: >10μM
PKCIC50: >10μM
PKCθIC50: >10μM
Chk1IC50: >10μM
EGFIC50: >10μM
IKK1IC50: >10μM
IKK2IC50: >10μM


Solubility (25°C) * In vitro DMSO 44 mg/mL (199.79 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 45.41 mL 227.07 mL 454.13mL
0.5 mM 9.08 mL 45.41 mL 90.83 mL
1 mM 4.54 mL 22.71 mL 45.41 mL
5 mM 0.91 mL 4.54 mL 9.08 mL

*The above data is based on the productmolecular weight 220.2 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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