SR-1277 is a potent and selective inhibitor of casein kinase 1 delta (CK1δ) and epsilon (CK1ε), demonstrating ATP-competitive inhibition with IC50 values of 49 nM and 260 nM, respectively. Additionally, it exhibits inhibitory effects on FLT3, CDK4/cyclin D1, CDK6/cyclin D3, and CDK9/cyclin K, with IC50 values of 305 nM, 1340 nM, 311 nM, and 109 nM, respectively. SR-1277 is primarily employed in cancer research, contributing to studies investigating CK1-mediated signaling pathways and therapeutic potential.
SR-1277 is a potent and selective inhibitor of casein kinase 1 delta (CK1δ) and epsilon (CK1ε), demonstrating ATP-competitive inhibition with IC50 values of 49 nM and 260 nM, respectively. Additionally, it exhibits inhibitory effects on FLT3, CDK4/cyclin D1, CDK6/cyclin D3, and CDK9/cyclin K, with IC50 values of 305 nM, 1340 nM, 311 nM, and 109 nM, respectively. SR-1277 is primarily employed in cancer research, contributing to studies investigating CK1-mediated signaling pathways and therapeutic potential.
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