SR-4133 is a selective inhibitor of Casein Kinase 1 epsilon (CK1ε) with an IC50 value of 58 nM. This compound binds effectively to the ATP-binding site of CK1ε, leading to significant inhibition of cell growth in bladder cancer models at nanomolar concentrations. Additionally, SR-4133 disrupts the phosphorylation of 4E-BP1, making it valuable for research applications in cancer biology and signaling pathways.
SR-4133 is a selective inhibitor of Casein Kinase 1 epsilon (CK1ε) with an IC50 value of 58 nM. This compound binds effectively to the ATP-binding site of CK1ε, leading to significant inhibition of cell growth in bladder cancer models at nanomolar concentrations. Additionally, SR-4133 disrupts the phosphorylation of 4E-BP1, making it valuable for research applications in cancer biology and signaling pathways.
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