SR2640 is a potent and selective antagonist of leukotriene D4 (LTD4) and leukotriene E4 (LTE4). It effectively inhibits LTD4-induced smooth muscle contractions in the guinea pig ileum and trachea without interfering with histamine-induced contractions. At a concentration of 23 nM, SR2640 prevents the binding of [3H] LTD4 to receptors in guinea pig lung tissue, demonstrating its high affinity. This compound is suitable for research applications related to asthma and bronchoconstriction, as it shifts the dose-response curve for LTD4-induced bronchoconstriction in guinea pigs to the right, correlating with the administered dose of SR2640.
SR2640 is a potent and selective antagonist of leukotriene D4 (LTD4) and leukotriene E4 (LTE4). It effectively inhibits LTD4-induced smooth muscle contractions in the guinea pig ileum and trachea without interfering with histamine-induced contractions. At a concentration of 23 nM, SR2640 prevents the binding of [3H] LTD4 to receptors in guinea pig lung tissue, demonstrating its high affinity. This compound is suitable for research applications related to asthma and bronchoconstriction, as it shifts the dose-response curve for LTD4-induced bronchoconstriction in guinea pigs to the right, correlating with the administered dose of SR2640.
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