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Biological Activity
SRPIN340 is a cell-permeable isonicotinamide that acts as an ATP-competitive SRPK1-selective inhibitor (IC50 = 0.14 and 1.8 μM, respectively, against mSRPK1 and mSRPK2) with much reduced activity against 143 other kinases.
Targets
| SRPK1 | ||||
| 0.89 μM(Ki) |
| In vitro (25°C) | DMSO | 67 mg/mL (191.78 mM) | |
| Water | Insoluble | ||
| Ethanol | 67 mg/mL (191.78 mM) | ||
| In vivo | 1% DMSO+30% polyethylene glycol+1% Tween 80 | 7 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 28.62 mL | 143.1 mL | 286.2 mL |
| 0.5 mM | 5.72 mL | 28.62 mL | 57.24 mL |
| 1 mM | 2.86 mL | 14.31 mL | 28.62 mL |
| 5 mM | 0.57 mL | 2.86 mL | 5.72 mL |
*The above data is based on the productmolecular weight 349.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A13188 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 218156-96-8 |
| Formula | C18H18F3N3O |
| M. Wt | 349.4 |
| Purity | >98% |
| Synonyms | SRPIN 340, SRPIN-340 |
| SMILES | C1CCN(CC1)C2=C(C=C(C=C2)C(F)(F)F)NC(=O)C3=CC=NC=C3 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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