SSR182289 is a selective and potent inhibitor of thrombin, demonstrating competitive inhibition with a Ki of 0.031 µM. This compound exhibits significant anticoagulant activity, achieving an EC100 of 96 nM in thrombin time assays, and effectively inhibits tissue factor-induced thrombin generation with an IC50 of 0.15 µM in human plasma. Additionally, SSR182289 inhibits thrombin-induced aggregation of human platelets with an IC50 of 32 nM, while showing no effect on aggregation induced by other agonists. Such properties make SSR182289 valuable for research into anticoagulation and thrombotic disorders.
SSR182289 is a selective and potent inhibitor of thrombin, demonstrating competitive inhibition with a Ki of 0.031 µM. This compound exhibits significant anticoagulant activity, achieving an EC100 of 96 nM in thrombin time assays, and effectively inhibits tissue factor-induced thrombin generation with an IC50 of 0.15 µM in human plasma. Additionally, SSR182289 inhibits thrombin-induced aggregation of human platelets with an IC50 of 32 nM, while showing no effect on aggregation induced by other agonists. Such properties make SSR182289 valuable for research into anticoagulation and thrombotic disorders.
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