SSTR5 antagonist 4 is a highly potent and selective antagonist of the somatostatin subtype 5 receptor (SSTR5), exhibiting IC50 values of 1.3 nM for human SSTR5 and 1.0 nM for mouse SSTR5. This compound demonstrates significant efficacy in the mouse oral glucose tolerance test (OGTT) in high fat diet-induced mice. SSTR5 antagonist 4 is a valuable tool for research into type 2 diabetes and related metabolic disorders.
SSTR5 antagonist 4 is a highly potent and selective antagonist of the somatostatin subtype 5 receptor (SSTR5), exhibiting IC50 values of 1.3 nM for human SSTR5 and 1.0 nM for mouse SSTR5. This compound demonstrates significant efficacy in the mouse oral glucose tolerance test (OGTT) in high fat diet-induced mice. SSTR5 antagonist 4 is a valuable tool for research into type 2 diabetes and related metabolic disorders.
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