STAT3 HiBiT degrader 1

Catalog No.: A36564
STAT3 HiBiT Degrader
STAT3 HiBiT Degrader 1 is a potent compound that selectively targets the signal transducer and activator of transcription 3 (STAT3) for degradation. It demonstrates a DC50 value of less than 0.05 μM in A549 cells, highlighting its efficacy in reducing STAT3 levels. This degrader offers valuable tools for studying the role of STAT3 in cancer and other diseases, facilitating the investigation of pathways regulated by this transcription factor.
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5mg
10mg
50mg
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Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
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Nature Volume 622 Issue 7982 (2023)
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Nature volume 574, pages268-272 (2019)
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Nature volume 551, pages639-643 (2017)
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Biological Activity
DescriptionSTAT3 HiBiT Degrader 1 is a potent compound that selectively targets the signal transducer and activator of transcription 3 (STAT3) for degradation. It demonstrates a DC50 value of less than 0.05 μM in A549 cells, highlighting its efficacy in reducing STAT3 levels. This degrader offers valuable tools for studying the role of STAT3 in cancer and other diseases, facilitating the investigation of pathways regulated by this transcription factor.
Product Information
Catalog NumA36564
FormulaC58H63F4N10O14PS
Molecular Weight1263.21
CAS Number2767166-30-1
SMILESFC(F)(P(O)(O)=O)C1=CC(C=C(C(N[C@H]2CN(C(OC)=O)CC[C@@H]3N([C@H](C(N[C@@H](CCC(N)=O)C(N[C@H](C(N4CCC(CCC#CC5=CC(N(C)C(N6C7C(NC(CC7)=O)=O)=O)=C6C=C5)CC4)=O)CC8=CC=C(F)C(F)=C8)=O)=O)CC3)C2=O)=O)S9)=C9C=C1
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