STING agonist-23 is a small-molecule STING agonist that functions non-nucleotidally to activate the STING pathway. This enhancement leads to increased phosphorylation of STING, TBK1, and IRF3, resulting in elevated production of key cytokines such as IFN-β, IL-6, CXCL-10, TNF-α, ISG-15, and CCL-5 in tumor cells. STING agonist-23 is also shown to exhibit antiviral activity against SARS-CoV strains, making it a valuable tool for immunotherapy and virology research.
STING agonist-23 is a small-molecule STING agonist that functions non-nucleotidally to activate the STING pathway. This enhancement leads to increased phosphorylation of STING, TBK1, and IRF3, resulting in elevated production of key cytokines such as IFN-β, IL-6, CXCL-10, TNF-α, ISG-15, and CCL-5 in tumor cells. STING agonist-23 is also shown to exhibit antiviral activity against SARS-CoV strains, making it a valuable tool for immunotherapy and virology research.
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