Catalog No.
Product Name
Application
Product Information
Citations
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human-specific STING agonist
STING agonist-1 (G10) is a novel human-specific STING agonist that elicits antiviral activity against emerging Alphaviruses. -
STING agonist
ADU-S100 (MIW815) is a synthetic cyclic dinucleotide (CDN) agonist (activator) of Stimulator of Interferon Genes (STING), a receptor crucial to activate the innate (endogenous) immune system. -
STING ligand
STING ligand-1 is a lead STING ligand with an IC50 of 68 nM for HAQ STING. -
STING receptor agonist
STING agonist-4 is an stimulator of Interferon Genes (STING) receptor agonist with an apparent inhibitory constant (IC50) of 20 nM. -
STING agonist
Cyclic-di-GMP is a STING agonist and a ubiquitous second messenger that regulates biofilm formation, motility, and virulence in diverse bacterial species. -
STING agonist
STING agonist-3, compound 3, is a selective and non-nucleotide small-molecule STING agonist, which has durable anti-tumor effect and tremendous potential to improve treatment of cancer. -
STING receptor agonist
diABZI STING agonist-1 is a selective stimulator of interferon genes (STING) receptor agonist, with an EC50s of 130 nM for human PBMCs. -
STING receptor agonist
diABZI STING agonist-1 (trihydrochloride) is a selective stimulator of interferon genes (STING) receptor agonist, with an EC50s of 130 for human PBMCs. -
STING activator
ADU-S100 ammonium salt (ML RR-S2 CDA ammonium salt; MIW815 ammonium salt), an activator of stimulator of interferon genes (STING), leads to potent and systemic tumor regression and immunity. -
STING PROTAC degrader
Anti-inflammatory agent 70 (N-Me-SP23) is a PROTAC-based degrader targeting the STING (stimulator of interferon genes) protein, a key regulator of innate immune and inflammatory responses. By promoting STING degradation, N-Me-SP23 effectively inhibits the STING signaling pathway, leading to reduced downstream inflammatory cytokine production. This compound exhibits notable anti-inflammatory activity and holds potential for therapeutic research in STING-associated autoimmune and inflammatory disorders. -
PROTAC STING Degrader
PROTAC STING Degrader-1 is a PROTAC degrader designed to target the STING (Stimulator of Interferon Genes) pathway, demonstrating a DC50 value of 3.2 μM. It exhibits pronounced anti-inflammatory effects, making it a valuable tool for investigating conditions such as acute kidney injury and inflammatory bowel diseases (IBDs). This compound can facilitate research into STING-mediated signaling and its role in various inflammatory processes. -
STING Inhibitor
STING-IN-17 is a potent inhibitor of STING (Stimulator of Interferon Genes), with human STING IC50 of 29 nM and mouse STING IC50 of 15 nM. This compound effectively inhibits the phosphorylation of STING, TBK1, and IRF3, leading to a dose-dependent reduction in the mRNA expression of key inflammatory markers such as IP10, IFNB1, and ISG56. STING-IN-17 also decreases reactive oxygen species (ROS) levels and inhibits the activation of apoptosis-related proteins cleaved-PARP and caspase-3. Its potential applications make it valuable for research into inflammatory conditions, particularly acute kidney injury. -
STING Agonist
M04 is a potent agonist of stimulator of interferon genes (STING), specifically activating the wild-type human STING in HEK293T cells while demonstrating no efficacy with the HAQ STING variant or in mouse RAW 264.7 cells. It effectively induces the expression of pro-inflammatory cytokines such as TNF-α, IL-10, IL-1β, and IL-12p70 in human peripheral blood mononuclear cells (PBMCs). At a concentration of 50 µM, M04 enhances dendritic cell maturation, promoting the expression of MHC class II (HLA-DR) and co-stimulatory molecules (CD40, CD80, CD86), thereby boosting T cell activation. This reagent is valuable for research in inflammatory immune diseases. -
STING Agonist
STING Agonist-45 is a selective agonist of the stimulator of interferon genes (STING), exhibiting an EC50 value of 0.28 μM. It activates the innate immune response via the cGAS-STING pathway, leading to the upregulation of critical markers such as p-TBK1 and IRF3. STING Agonist-45 effectively stimulates the production of type I interferons, including IFN-β, as well as cytokines like TNF-α and IL-6 in human peripheral blood mononuclear cells (PBMCs). This compound shows potential in enhancing anti-tumor immunity, inhibiting tumor growth, and promoting CD8+ T cell infiltration in animal models, making it a valuable tool for research into STING-related diseases. -
STING Activator
PDIC-NN dimethanesulfonate is a potent STING activator known for its anticancer properties. It enhances the stability and levels of endogenous cyclic dinucleotides (CDNs), triggering a reactive oxygen species (ROS) burst that damages mitochondria, thereby inducing apoptosis and inhibiting DNA replication. By activating the cGAS-STING signaling pathway, PDIC-NN dimethanesulfonate boosts the immunogenicity of tumor cells and stimulates a robust innate immune response, making it a valuable reagent for cancer immunotherapy research. -
STING Inhibitor
STING-IN-16 is a potent inhibitor of the Stimulator of Interferon Genes (STING) pathway, exhibiting IC50 values of 44 nM in human cells and 32 nM in murine cells. It effectively inhibits STING activation, leading to restoration of renal mitochondrial function, reduction of reactive oxygen species (ROS) production, and decreased cell apoptosis. With demonstrated anti-inflammatory efficacy in vivo, STING-IN-16 is valuable for research focused on autoimmune and autoinflammatory diseases. -
STING Activator
PDIC-NN is a potent STING (Stimulator of Interferon Genes) activator that demonstrates significant anticancer activity. This compound enhances the stability and levels of endogenous cyclic dinucleotides (CDNs), triggering reactive oxygen species (ROS) production and inducing mitochondrial damage. Additionally, PDIC-NN promotes cell apoptosis and inhibits DNA replication while activating the cGAS-STING signaling pathway, thereby augmenting the immunogenicity of tumor cells and eliciting a robust innate immune response. This makes PDIC-NN a valuable tool for studying immune modulation and therapeutic strategies in cancer research. -
STING Agonist
PDIC-NC is a STING agonist that promotes the activation of the STING pathway, leading to enhanced immune responses against tumors. This compound is cytotoxic to tumor cells and induces reactive oxygen species (ROS) production, as well as apoptosis and autophagy. With its specific distribution to lung tissue, PDIC-NC is particularly valuable for research applications focused on lung cancer. -
STING Inhibitor
STING-IN-11 is a potent STING inhibitor with an IC50 of 37.8 nM. By blocking the palmitoylation of the STING protein, it effectively inhibits STING-mediated downstream signaling and associated inflammatory pathways. This compound demonstrates favorable in vivo safety, making it an excellent candidate for research into STING-related inflammatory and autoimmune diseases. -
STING Agonist
STING Agonist-50 is a potent oral STING agonist that activates the STING signaling pathway with an IC50 of 3.457 μM. It facilitates the phosphorylation of downstream proteins TBK1 and IRF3, leading to the enhanced expression of key cytokines such as IFN-β, CXCL10, and IL-6. This compound has demonstrated the ability to inhibit tumor growth in syngeneic mouse models, making it a valuable tool for research focused on colorectal cancer. -
STING Activator
c-(2'FdAMP-2'FdIMP) is a cyclic dinucleotide (CDN) that functions as a STING activator. It effectively stimulates STING-dependent signaling pathways, including IRF and NF-κB, leading to enhanced immune responses. This compound is valuable for research into STING-based immunotherapy applications, particularly in the context of cancer and infectious disease studies. -
STING Agonist
2',3'-cGAMP-C2-PPA is a cyclic dinucleotide that acts as a STING (Stimulator of Interferon Genes) agonist. It modulates immune responses by stimulating the production of interferons and other cytokines, making it a valuable tool in cancer immunotherapy research. This compound is particularly useful for studying immune responses in tumor microenvironments and exploring therapeutic strategies for cancer treatment. -
STING Agonist
STING agonist-18 diTFA is a potent STING (Stimulator of Interferon Genes) agonist that activates the STING pathway, leading to enhanced immune responses. This compound is useful for the synthesis of antibody-drug conjugates (ADCs), enabling targeted delivery of therapeutics. Its potential applications in cancer immunotherapy and other immune-mediated therapies make it a valuable reagent for research in drug development and immunological studies. -
STING Agonist
STING agonist-49 is a powerful stimulator of the STING (Stimulator of Interferon Genes) pathway, engaging the immune response through Type I interferon production. This compound demonstrates potent biological activity in modulating immune responses, making it a valuable tool in lung cancer research. STING agonist-49 can also serve as an effective payload in antibody-drug conjugates (ADCs), enhancing targeted therapeutic approaches in various malignancies. -
STING Agonist
STING agonist-18 is a potent agonist of the stimulator of interferon genes (STING) pathway, known for its ability to activate immune responses. This compound is particularly useful in the synthesis of antibody-drug conjugates (ADCs), such as Trastuzumab conjugates, facilitating targeted therapeutic approaches. Its application in cancer immunotherapy and related research enhances the understanding of STING pathway modulation in tumor microenvironments. -
STING Agonist
c-di-AMP disodium is a cyclic dinucleotide serving as a STING agonist, which interacts with the STING protein to activate the TBK1-IRF3 signaling pathway. This activation leads to the production of type I interferons and tumor necrosis factor, playing a pivotal role in the immune response. In addition to its function in immune modulation, c-di-AMP is a bacterial second messenger that regulates various physiological processes in Gram-positive bacteria, including growth and virulence. Its properties also make it an effective mucosal adjuvant for enhancing both humoral and cellular immune responses in research applications. -
STING Agonist
STING Agonist-30 is a potent agonist that activates the Stimulator of Interferon Genes (STING) pathway. This compound elicits a robust immune response and enhances STING-dependent immune activation. It demonstrates significant antiviral activity against a range of viruses, including herpes simplex virus (HSV), rotavirus, and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), making it valuable for research in antiviral therapies and immune modulation. -
STING Activator
diABZI-4 is a potent STING activator that enhances the host immune response through immunostimulatory activity. By promoting STING oligomerization, diABZI-4 activates the TBK1-IRF3 and NF-κB signaling pathways, leading to increased production of type I/III interferons and proinflammatory cytokines. This reagent demonstrates broad-spectrum antiviral efficacy against various viruses, including influenza A, SARS-CoV-2, and herpes simplex virus. diABZI-4 is instrumental in research related to COVID-19, respiratory viral infections, and the associated immunopathological mechanisms, making it a valuable tool for studying viral pathogenesis and developing therapeutic strategies. -
STING Inhibitor
SN-011 is a selective inhibitor of the STING pathway, displaying an IC50 of 76 nM. By competing with cyclic dinucleotides (CDNs) for the binding site on the STING dimer, SN-011 effectively prevents CDN binding and subsequent STING activation. This compound is valuable for investigating STING-mediated autoimmune and inflammatory diseases, offering insights into therapeutic strategies targeting this critical signaling pathway. -
STING Inhibitor
STING-IN-2 is a potent covalent inhibitor of Stimulator of Interferon Genes (STING), effectively targeting both mouse and human STING isoforms. This compound is instrumental in studying the role of STING in autoinflammatory diseases, facilitating the exploration of therapeutic interventions. Its ability to modulate STING activity makes it a valuable tool for researchers investigating immune response and signaling pathways. -
Second Messenger/STING Agonist
Cyclic-di-GMP disodium functions as a STING agonist and serves as a crucial bacterial second messenger. It orchestrates various bacterial behaviors such as motility, virulence, biofilm formation, and cell cycle regulation. Additionally, cyclic-di-GMP disodium exhibits anti-cancer activity by inhibiting cell proliferation and promoting CD4 receptor expression along with inducing cell cycle arrest. This compound is valuable for applications in cancer research. -
STING Activator
cGAMP disodium, a potent STING activator, functions as an endogenous second messenger that triggers the production of interferons in response to cytosolic DNA. It initiates the stimulator of interferon genes (STING) pathway, resulting in an immune response marked by the production of type I interferons and various immune mediators. This compound is widely used in research focused on innate immunity, cancer immunotherapy, and understanding viral infections. -
STING Activator
STING agonist-12 (Compound 53) is a potent agonist that activates the human stimulator of interferon genes (STING) pathway, exhibiting an EC50 value of 185 nM. This compound serves as a valuable tool for immunological research, particularly in studying innate immune responses and antitumor immunity. Its ability to modulate STING activity makes it a promising candidate for assessing therapeutic strategies in cancer and infectious diseases. -
STING Molecular Glue
NVS-STG2 is a molecular glue that targets the STING receptor by binding to the interstitial regions of adjacent STING dimers, thereby enhancing STING signaling. This compound promotes the activity of cGAMP, leading to the formation of larger and more stable oligomers, which amplifies the immune response. NVS-STG2 has demonstrated significant antitumor effects in preclinical animal models, making it a valuable tool for cancer immunotherapy research. -
STING Agonist
STING agonist-20 is a potent agonist of the STING pathway, which plays a critical role in the innate immune response. This compound is utilized in the synthesis of XMT-2056, serving as an important tool in cancer research and the investigation of inflammatory and immune-related diseases. Its application as a vaccine adjuvant allows for enhanced immune activation, making it a valuable reagent in immunotherapy studies. -
STING Agonist
STING Agonist-22 (CF501) is a potent non-nucleotide agonist targeting the stimulator of interferon genes (STING). This compound effectively activates STING to induce a type I interferon (IFN-I) response and drive the production of proinflammatory cytokines. STING Agonist-22 serves as an adjuvant to enhance protein vaccine efficacy, promoting robust and sustained immune protection. It is particularly relevant for research on SARS-CoV-2 variants and related sarbecovirus diseases. -
STING Antagonist
STING antagonist-1 is a selective antagonist of the Stimulator of Interferon Genes (STING) pathway, exhibiting an IC50 of 3.8 nM. This compound is valuable for research applications related to autoimmune and inflammatory diseases, allowing for the investigation of STING-mediated cellular responses and therapeutic interventions. -
Second Messenger/STING Agonist
Cyclic-di-GMP diammonium is a second messenger with significant activity as a STING agonist. It plays a crucial role in regulating bacterial growth, motility, virulence, biofilm formation, and cell cycle progression. In addition to its bacterial applications, cyclic-di-GMP diammonium demonstrates anti-cancer properties, promoting cell cycle arrest and increasing CD4 receptor expression. This reagent is valuable for investigations in cancer research. -
STING Inhibitor
LB244 is a STING inhibitor that functions by modulating the STING signaling pathway to reduce inflammation. It exhibits a potent inhibitory effect (EC50 = 0.8 μM) on STING-dependent inflammatory responses. While LB244 shows promising potential in preclinical studies, its pharmacokinetic profile suggests limited oral bioavailability in murine models. This compound is suitable for research applications focused on understanding STING-related inflammatory disorders. -
STING Agonist
E7766 diammonium salt is a macrocycle-bridged STING agonist that exhibits a dissociation constant (Kd) of 40 nM. This compound demonstrates potent pan-genotypic activity and significant antitumor effects, making it a valuable tool for cancer immunotherapy research. It is suitable for studies focused on modulating the STING pathway to enhance immune responses against tumors.
