STING Agonist-45 is a selective agonist of the stimulator of interferon genes (STING), exhibiting an EC50 value of 0.28 μM. It activates the innate immune response via the cGAS-STING pathway, leading to the upregulation of critical markers such as p-TBK1 and IRF3. STING Agonist-45 effectively stimulates the production of type I interferons, including IFN-β, as well as cytokines like TNF-α and IL-6 in human peripheral blood mononuclear cells (PBMCs). This compound shows potential in enhancing anti-tumor immunity, inhibiting tumor growth, and promoting CD8+ T cell infiltration in animal models, making it a valuable tool for research into STING-related diseases.
STING Agonist-45 is a selective agonist of the stimulator of interferon genes (STING), exhibiting an EC50 value of 0.28 μM. It activates the innate immune response via the cGAS-STING pathway, leading to the upregulation of critical markers such as p-TBK1 and IRF3. STING Agonist-45 effectively stimulates the production of type I interferons, including IFN-β, as well as cytokines like TNF-α and IL-6 in human peripheral blood mononuclear cells (PBMCs). This compound shows potential in enhancing anti-tumor immunity, inhibiting tumor growth, and promoting CD8+ T cell infiltration in animal models, making it a valuable tool for research into STING-related diseases.
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