STING agonist-48 is a selective agonist that activates the Stimulator of Interferon Genes (STING) pathway, demonstrating an EC50 value of 4.02 μM in vitro. It preferentially binds to the transmembrane domain, influencing downstream immune responses. This compound enhances immunogenicity by promoting IgG and Th1/Th2 cytokine responses in humanized STING mice, making it a valuable tool for investigating inflammation-related diseases and potential adjuvant therapies.
STING agonist-48 is a selective agonist that activates the Stimulator of Interferon Genes (STING) pathway, demonstrating an EC50 value of 4.02 μM in vitro. It preferentially binds to the transmembrane domain, influencing downstream immune responses. This compound enhances immunogenicity by promoting IgG and Th1/Th2 cytokine responses in humanized STING mice, making it a valuable tool for investigating inflammation-related diseases and potential adjuvant therapies.
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