SU015 is an antagonist of the integrins αvβ3 and αvβ5, demonstrating comparable affinity for both targets with enhanced potency and specificity. This compound effectively inhibits αvβ3-mediated cell adhesion to fibrinogen and osteopontin, as well as αvβ5-mediated cell adhesion to vitronectin. Additionally, SU015 exhibits significant inhibitory effects on FGF2-induced angiogenesis in the chick embryo chorioallantoic membrane (CAM) model. Its properties allow for potential applications in tumor metastasis studies, and it features a linker arm suitable for radioisotope conjugation, serving as a target-specific radioreagent when labeled with isotopes such as 90Y or 177Lu.
SU015 is an antagonist of the integrins αvβ3 and αvβ5, demonstrating comparable affinity for both targets with enhanced potency and specificity. This compound effectively inhibits αvβ3-mediated cell adhesion to fibrinogen and osteopontin, as well as αvβ5-mediated cell adhesion to vitronectin. Additionally, SU015 exhibits significant inhibitory effects on FGF2-induced angiogenesis in the chick embryo chorioallantoic membrane (CAM) model. Its properties allow for potential applications in tumor metastasis studies, and it features a linker arm suitable for radioisotope conjugation, serving as a target-specific radioreagent when labeled with isotopes such as 90Y or 177Lu.
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