t-Boc-N-amido-PEG4-Val-Cit is a protease-cleavable linker designed for antibody-drug conjugates (ADCs). This compound consists of a Boc-protected amine, a hydrophilic polyethylene glycol (PEG) spacer, and a Val-Cit dipeptide that can be cleaved by cellular proteases. The resulting carboxylic acid facilitates coupling reactions with amines to form amides. Upon removal of the Boc group under acidic conditions, a free primary amine is available for diverse chemical reactions, including coupling and reductive amination, making it a versatile tool in ADC development and modification.
t-Boc-N-amido-PEG4-Val-Cit is a protease-cleavable linker designed for antibody-drug conjugates (ADCs). This compound consists of a Boc-protected amine, a hydrophilic polyethylene glycol (PEG) spacer, and a Val-Cit dipeptide that can be cleaved by cellular proteases. The resulting carboxylic acid facilitates coupling reactions with amines to form amides. Upon removal of the Boc group under acidic conditions, a free primary amine is available for diverse chemical reactions, including coupling and reductive amination, making it a versatile tool in ADC development and modification.
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