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Taccalonolide B

Catalog No.: A54832
Microtubule/Tubulin Inhibitor
Taccalonolide B is a microtubule stabilizer that targets tubulin, exhibiting notable antitumor activity. This compound demonstrates efficacy in vitro against cell lines with overexpression of P-glycoprotein (Pgp) and multidrug-resistance protein 7 (MRP7). Taccalonolide B effectively inhibits the growth of SK-OV-3 cells, yielding an IC50 value of 208 nM, making it a valuable tool for cancer research and drug resistance studies.
Taccalonolide B 108885-69-4 Microtubule/Tubulin Inhibitor
Grouped product items
Size Price Stock Qty
1mg
$40.00
In stock
5mg
$95.00
In stock
10mg
$165.00
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionTaccalonolide B is a microtubule stabilizer that targets tubulin, exhibiting notable antitumor activity. This compound demonstrates efficacy in vitro against cell lines with overexpression of P-glycoprotein (Pgp) and multidrug-resistance protein 7 (MRP7). Taccalonolide B effectively inhibits the growth of SK-OV-3 cells, yielding an IC50 value of 208 nM, making it a valuable tool for cancer research and drug resistance studies.
Product Information
Catalog NumA54832
FormulaC34H44O13
Molecular Weight660.71
CAS Number108885-69-4
SMILESC[C@]1([C@]2([H])C[C@H](O3)[C@H]3[C@@H]1OC(C)=O)[C@]4([H])[C@]([C@@H](O)C2=O)([H])[C@@]5([H])[C@@](C)([C@]6([H])[C@@]([C@](C(OC7=O)=C[C@H]6C)([C@@]7(O)C)C)([H])[C@@H]5O)[C@@H](OC(C)=O)[C@H]4OC(C)=O
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Cytoskeleton > Microtubule/Tubulin