TAK-875 (Fasiglifam)

Catalog No.: A11018

GPR agonist

TAK-875 (Fasiglifam)

TAK-875 (Fasiglifam) Chemical Structure

CAS NO. 1000413-72-8

TAK-875 is a potent, selective, and orally bioavailable GPR40 agonist.

Availability: In stock

Package Price Qty
5 mg
$100.00
10 mg
$150.00
50 mg
$450.00
100 mg
$720.00
10mM * 1mL in DMSO
$110.00
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Ying Liu, .et al. A synthetic free fatty acid-regulated transgene switch in mammalian cells and mice, Nucleic Acids Res, 2018, Oct 12; 46(18): 9864-9874 PMID: 30219861
  • Deborah A. Goldspink, .et al. Mechanistic insights into the detection of free fatty and bile acids by ileal glucagon-like peptide-1 secreting cells, Mol Metab, 2018, Jan; 7: 90-101 PMID: 29167062
  • Hodaka Yamada, .et al. Potentiation of Glucose-stimulated Insulin Secretion by the GPR40-PLC-TRPC Pathway in Pancreatic β-Cells, Sci Rep, 2016, 6: 25912 PMID: 27180622

Biological Activity

TAK-875 is a potent, selective, and orally bioavailable GPR40 agonist.
In vitro (25°C) DMSO 100 mg/mL (187.39 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 0.5% CMC/0.25% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18.74 mL 93.7 mL 187.41 mL
0.5 mM 3.75 mL 18.74 mL 37.48 mL
1 mM 1.87 mL 9.37 mL 18.74 mL
5 mM 0.37 mL 1.87 mL 3.75 mL

*The above data is based on the productmolecular weight 533.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11018
Actions Agonist
M. Wt 533.6
Formula C29H32O7S.1/2H2O
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1000413-72-8
Synonyms TAK875
SMILES CC1=CC(=CC(=C1C2=CC(=CC=C2)COC3=CC4=C(C=C3)[[email protected]@H](CO4)CC(=O)O)C)OCCCS(=O)(=O)C

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