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$0.00 - Ying Liu, .et al. A synthetic free fatty acid-regulated transgene switch in mammalian cells and mice, Nucleic Acids Res, 2018, Oct 12; 46(18): 9864-9874 PMID: 30219861
- Deborah A. Goldspink, .et al. Mechanistic insights into the detection of free fatty and bile acids by ileal glucagon-like peptide-1 secreting cells, Mol Metab, 2018, Jan; 7: 90-101 PMID: 29167062
- Hodaka Yamada, .et al. Potentiation of Glucose-stimulated Insulin Secretion by the GPR40-PLC-TRPC Pathway in Pancreatic β-Cells, Sci Rep, 2016, 6: 25912 PMID: 27180622
Biological Activity
TAK-875 is a potent, selective, and orally bioavailable GPR40 agonist.
| In vitro (25°C) | DMSO | 92 mg/mL (172.4 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
| In vivo | 0.5% CMC+0.25% Tween 80 | 28 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 19.06 mL | 95.31 mL | 190.62 mL |
| 0.5 mM | 3.81 mL | 19.06 mL | 38.12 mL |
| 1 mM | 1.91 mL | 9.53 mL | 19.06 mL |
| 5 mM | 0.38 mL | 1.91 mL | 3.81 mL |
*The above data is based on the productmolecular weight 524.6. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A11018 |
|---|---|
| Actions | Agonist |
| CAS No. | 1000413-72-8 |
| Formula | C29H32O7S |
| M. Wt | 524.6 |
| Purity | >98% |
| Synonyms | TAK875 |
| SMILES | CC1=C(C2=CC(COC3=CC=C([[email protected]](CC(O)=O)CO4)C4=C3)=CC=C2)C(C)=CC(OCCCS(C)(=O)=O)=C1 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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