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Publications citing Adooq Products
TAK-875 (Fasiglifam) Citations (3)
- Ying Liu, .et al. A synthetic free fatty acid-regulated transgene switch in mammalian cells and mice, Nucleic Acids Res, 2018, Oct 12; 46(18): 9864每9874 PMID: 30219861
- Deborah A. Goldspink, .et al. Mechanistic insights into the detection of free fatty and bile acids by ileal glucagon-like peptide-1 secreting cells, Mol Metab, 2018, Jan; 7: 90每101 PMID: 29167062
- Hodaka Yamada, .et al. Potentiation of Glucose-stimulated Insulin Secretion by the GPR40每PLC每TRPC Pathway in Pancreatic 汕-Cells, Sci Rep, 2016, 6: 25912 PMID: 27180622
Chemical Information
| Catalog Num | A11018 |
|---|---|
| Actions | Agonist |
| M. Wt | 533.6 |
| Formula | C29H32O7S.1/2H2O |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 1000413-72-8 |
| Synonyms | TAK875 |
| SMILES | CC1=CC(=CC(=C1C2=CC(=CC=C2)COC3=CC4=C(C=C3)[[email protected]@H](CO4)CC(=O)O)C)OCCCS(=O)(=O)C |
| Chemical Name | [(3S)-6-({2′,6′-dimethyl-4′-[3-(methylsulfonyl)propoxy]biphenyl-3-yl}methoxy)-2,3-dihydro-1-benzofuran-3-yl]acetic acid hemi-hydrate |
Description |
TAK-875 is a potent, selective, and orally bioavailable GPR40 agonist. | |||||
| Solubility (25°C) * | In vitro | DMSO | 100 mg/mL (187.39 mM) |
|---|---|---|---|
| Water | <1 mg/mL (<1 mM) | ||
| Ethanol | <1 mg/mL (<1 mM) | ||
| In vivo | 0.5% CMC/0.25% Tween 80 | 30 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 18.74 mL | 93.7 mL | 187.41mL |
| 0.5 mM | 3.75 mL | 18.74 mL | 37.48 mL |
| 1 mM | 1.87 mL | 9.37 mL | 18.74 mL |
| 5 mM | 0.37 mL | 1.87 mL | 3.75 mL |
*The above data is based on the productmolecular weight 533.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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