TAS-102

Catalog No.: A15533

Trifluridine-tipiracil hydrochloride mixture

TAS-102

TAS-102 Chemical Structure

CAS NO. 733030-01-8

TAS-102 is an orally bioavailable combination agent composed of the cytotoxic pyrimidine analog Trifluridine (5-trifluoro-2??-deoxythymidine or TFT) and a thymidine phosphorylase inhibitor (TPI) tipiracil hydrochloride, in a molar ratio of 1.0:0.5 (TFT:TPI), with potential antineoplastic activity,

Availability: In stock

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2 mg

Regular Price: $40.00

Special Price $32.00

5 mg

Regular Price: $55.00

Special Price $44.00

10 mg

Regular Price: $90.00

Special Price $72.00

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Biological Activity

TAS-102 is an orally bioavailable combination agent composed of the cytotoxic pyrimidine analog Trifluridine (5-trifluoro-2??-deoxythymidine or TFT) and a thymidine phosphorylase inhibitor (TPI) tipiracil hydrochloride, in a molar ratio of 1.0:0.5 (TFT:TPI), with potential antineoplastic activity,
In vitro DMSO Warmed: 88 mg/mL (100.97 mM)
Water Warmed: 13 mg/mL (14.92 mM)
Ethanol 88 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 11.47 mL 57.37 mL 114.74 mL
0.5 mM 2.29 mL 11.47 mL 22.95 mL
1 mM 1.15 mL 5.74 mL 11.47 mL
5 mM 0.23 mL 1.15 mL 2.29 mL

*The above data is based on the productmolecular weight 871.53. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A15533
CAS No. 733030-01-8
Formula C29H34Cl2F6N8O12
M. Wt 871.53
Purity >98%
Synonyms TAS102, TAS 102
SMILES O=C1NC(C(C(F)(F)F)=CN1[[email protected]@H]2O[[email protected]](CO)[[email protected]@H](O)C2)=O.O=C3NC(C(Cl)=C(CN4C(CCC4)=N)N3)=O.[H]Cl
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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