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TAS4464 (hydrochloride) is a highly potent and selective inhibitor of NEDD8 activating enzyme (NAE), with an IC50 of 0.955 nM.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 18.42 mL | 92.09 mL | 184.17 mL |
| 0.5 mM | 3.68 mL | 18.42 mL | 36.83 mL |
| 1 mM | 1.84 mL | 9.21 mL | 18.42 mL |
| 5 mM | 0.37 mL | 1.84 mL | 3.68 mL |
*The above data is based on the productmolecular weight 542.97. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A21708 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 1848959-11-4 |
| Formula | C21H24ClFN6O6S |
| M. Wt | 542.97 |
| Solubility | DMSO |
| Purity | >98% |
| Synonyms | TAS 4464, TAS-4464 |
| SMILES | NC1=NC=NC2=C1C(C#CC3=C(F)C=CC=C3OCC)=CN2[[email protected]@H]4O[[email protected]](CNS(=O)(N)=O)[[email protected]@H](O)[[email protected]]4O.Cl |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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