Taurolithocholic acid 3-sulfate disodium is an agonist of the GPR39 receptor, demonstrating EC50 values of 71.6 μM and 69.4 μM in the absence of Zn2+ and 9 μM and 9.6 μM in the presence of Zn2+, as observed in M39-20 and hGPR39-2 cell lines, respectively. This compound activates GPR39 to promote intracellular calcium signaling while functioning independently of Zn2+ binding sites H17 and H19. Taurolithocholic acid 3-sulfate disodium is suitable for investigations related to gallbladder disease and its underlying mechanisms.
Taurolithocholic acid 3-sulfate disodium is an agonist of the GPR39 receptor, demonstrating EC50 values of 71.6 μM and 69.4 μM in the absence of Zn2+ and 9 μM and 9.6 μM in the presence of Zn2+, as observed in M39-20 and hGPR39-2 cell lines, respectively. This compound activates GPR39 to promote intracellular calcium signaling while functioning independently of Zn2+ binding sites H17 and H19. Taurolithocholic acid 3-sulfate disodium is suitable for investigations related to gallbladder disease and its underlying mechanisms.
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