TB-21007 is a potent inverse agonist targeting the α5 subunit of the GABAA receptor, exhibiting Ki values of 1.6 nM, 20 nM, 16 nM, and 20 nM for the α5, α1, α2, and α3 subtypes, respectively. This compound demonstrates significant brain penetration and is shown to enhance cognitive function in preclinical models, making it a valuable tool for research into cognitive disorders and neuropharmacology. Its selective action on α5-containing GABAA receptors positions it as a promising candidate for investigations into memory and learning.
TB-21007 is a potent inverse agonist targeting the α5 subunit of the GABAA receptor, exhibiting Ki values of 1.6 nM, 20 nM, 16 nM, and 20 nM for the α5, α1, α2, and α3 subtypes, respectively. This compound demonstrates significant brain penetration and is shown to enhance cognitive function in preclinical models, making it a valuable tool for research into cognitive disorders and neuropharmacology. Its selective action on α5-containing GABAA receptors positions it as a promising candidate for investigations into memory and learning.
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