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TCO-PEG3-Glu-Val-Cit-PABC-MMAF

Catalog No.: A41501
Drug-Linker Conjugate
TCO-PEG3-Glu-Val-Cit-PABC-MMAF is a drug-linker conjugate designed for targeted delivery in antibody-drug conjugate (ADC) applications. It incorporates a trans-cyclooctene (TCO) moiety for efficient click chemistry attachment, a polyethylene glycol (PEG) spacer for solubility enhancement, and a cleavable linker (Glu-Val-Cit) that releases the potent cytotoxic agent MMAF upon internalization. This reagent is ideal for advancing research in targeted cancer therapeutics and ADC development.
TCO-PEG3-Glu-Val-Cit-PABC-MMAF 2862795-63-7 Drug-Linker Conjugate
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionTCO-PEG3-Glu-Val-Cit-PABC-MMAF is a drug-linker conjugate designed for targeted delivery in antibody-drug conjugate (ADC) applications. It incorporates a trans-cyclooctene (TCO) moiety for efficient click chemistry attachment, a polyethylene glycol (PEG) spacer for solubility enhancement, and a cleavable linker (Glu-Val-Cit) that releases the potent cytotoxic agent MMAF upon internalization. This reagent is ideal for advancing research in targeted cancer therapeutics and ADC development.
Product Information
Catalog NumA41501
FormulaC80H126N12O22
Molecular Weight1607.92
CAS Number2862795-63-7
SMILESO=C(N(C)[C@@H](C(C)C)C(N[C@@H](C(C)C)C(N(C)[C@@H]([C@@H](C)CC)[C@H](OC)CC(N(CCC1)[C@]1([H])[C@H](OC)[C@@H](C)C(N[C@H](C(O)=O)CC2=CC=CC=C2)=O)=O)=O)=O)OCC(C=C3)=CC=C3NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC([C@H](CCC(O)=O)NC(COCCOCCOCCNC(OC4CC/C=C\CCC4)=O)=O)=O)=O)=O
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Click Chemistry > TCO