Catalog No.
Product Name
Application
Product Information
Citations
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Click Chemistry
Thiobis-β-Galactose-propyne serves as a versatile click chemistry reagent with an alkyne functional group, enabling copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions. Primarily, it acts as a multivalent inhibitor of galectin-3 (Gal-3), a protein implicated in various metabolic processes associated with cancer progression. This compound is suitable for applications in biochemical research focused on galectin-3-related pathways and provides a valuable tool for the development of targeted therapeutic strategies. - DBCO-NHS ester 2 is a cleavable linker that is used for making antibody-drug conjugate (ADC). DBCO-NHS ester 2 is a derivative of Dibenzylcyclooctyne (DBCO) used in copper-free click chemistry.
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S-IIP inhibitor/KRASG12C Probe
ARS-1323-Alkyne is a novel KRASG12C occupancy probe. -
BET inhibitor
JQ1-TCO (JQ1-trans-cyclooctene) is a derivative of JQ1, a BET inhibitor, modified for click chemistry applications. It serves as a molecular probe for in vitro and in vivo studies. -
NAT10 Inhibitor
CPTH2-Alkyne is a selective inhibitor of N-acetyltransferase 10 (NAT10), which plays a crucial role in cellular processes. This compound exhibits distinctive localization, accumulating in nucleoli and associating with the nuclear periphery and cytoplasm. CPTH2-Alkyne is utilized in research focused on nuclear architecture and has potential applications in the study of laminopathies, aiding the understanding of cellular structural dynamics. -
Btk Inhibitor
(Rac)-Ibrutinib alkyne is a potent Bruton's tyrosine kinase (Btk) inhibitor with an IC50 of 0.72 nM. This compound effectively disrupts B-cell receptor signaling, demonstrated by an IC50 of 9 nM for inhibiting calcium flux in Ramos cells. (Rac)-Ibrutinib alkyne is suitable for investigating various Btk-related pathologies, including rheumatoid arthritis and other immune disorders. -
Drug-Linker Conjugate for ADC
DBCO-HS-PEG2-VA-PABC-SG3199 is a drug-linker conjugate designed for antibody-drug conjugate (ADC) applications. It features a SG3199-based DNA small channel crosslinker combined with a cleavable linker, facilitating targeted delivery of therapeutic agents. This reagent is suitable for the synthesis of ADCs, enabling enhanced efficacy in drug-based cancer therapies and other biomedical research applications. -
Phosphatase Marker
5-FAM-Alkyne is a selective fluorescent biosensor targeting alkaline phosphatase (ALP) activity. This compound incorporates an alkyne group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. Its high sensitivity makes it a valuable tool for studying ALP-related biological processes and for applications in bioorthogonal labeling in chemical biology research. -
Drug-Linker Conjugate
TCO-PEG3-Glu-Val-Cit-PABC-MMAF is a drug-linker conjugate designed for targeted delivery in antibody-drug conjugate (ADC) applications. It incorporates a trans-cyclooctene (TCO) moiety for efficient click chemistry attachment, a polyethylene glycol (PEG) spacer for solubility enhancement, and a cleavable linker (Glu-Val-Cit) that releases the potent cytotoxic agent MMAF upon internalization. This reagent is ideal for advancing research in targeted cancer therapeutics and ADC development. -
Drug-linker Conjugate
DBCO-PEG3-Glu-Val-Cit-PABC-MMAE is a drug-linker conjugate designed for antibody-drug conjugate (ADC) applications. This compound incorporates the potent tubulin inhibitor Monomethyl auristatin E (MMAE), facilitating targeted delivery in cancer therapeutics. Its structural features enable effective synthesis of dual-drug ADCs, enhancing cytotoxic efficacy while minimizing off-target effects. -
Bifunctional Chelating Agent
Deferoxamine-DBCO is a bifunctional chelating agent that effectively binds to radioactive metals, such as 89Zr, via its deferoxamine (DFO) structure for radiolabeling applications. Additionally, it facilitates metal-free Huisgen cycloaddition reactions with azide-containing biomolecules, including siRNA and monoclonal antibodies, through its dibenzocyclooctyne (DBCO) moiety under bioorthogonal conditions. This reagent combines robust metal-chelating capabilities with specific bioorthogonal reactivity, making it suitable for targeted radioactive imaging studies in oncology research. -
Bifunctional Chelator
BCN-NODAGA is a bifunctional chelator that effectively binds to radionuclides, facilitating the formation of radionuclide conjugates (RDCs). This compound allows for targeted delivery to biomolecules, making it a valuable tool for medical imaging applications and therapeutic strategies. Its ability to form stable complexes enhances its utility in radiopharmaceutical development for diagnostics and treatment in oncology and other diseases. -
Bifunctional Chelator
BCN-DOTA is a bifunctional chelator that features a cyclooctyne linkage, allowing for the efficient radiolabeling with zirconium-89. This compound serves as a versatile radionuclide-labeled drug conjugate (RDC) designed for targeting specific biomolecules, cells, or tissues in vivo. BCN-DOTA is applicable in various research fields, including theranostics, molecular imaging, and targeted radiotherapy, enabling precise delivery and tracking of therapeutic agents. -
Bifunctional Chelator
BCN-DOTA-GA is a bifunctional chelator characterized by a cyclooctyne linkage and DOTA moiety. This reagent allows for efficient labeling with radioactive zirconium-89, enabling its use as a radionuclide-labeled drug conjugate (RDC). BCN-DOTA-GA is suitable for targeted applications in molecular imaging and radiotherapy, facilitating precise interactions with specific biomolecules, cells, or tissues in various research settings. -
ADC Linker
BCN-linker-DXd 2 is a specialized ADC (antibody-drug conjugate) linker designed for targeted delivery of cytotoxic agents to cancer cells. This compound facilitates the conjugation of drugs to antibodies, enhancing specificity and reducing off-target effects in cancer therapy. It is applicable in research focused on ADC development and optimization for improved therapeutic efficacy against various types of tumors. -
Drug-Linker Conjugate for ADC
DBCO-PEG4-VC-PAB-MMAE is a conjugate designed for use in antibody-drug conjugate (ADC) synthesis, incorporating a drug-linker element. The DBCO component facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with azide-containing molecules. The included MMAE moiety, a potent inhibitor of tubulin polymerization derived from dolastatin 10, exhibits significant mitotic inhibition. This reagent is ideal for advancing research in targeted cancer therapies by enabling the precise delivery of cytotoxic agents to tumor cells. -
Drug-Linker Conjugates for ADC
DBCO-PEG4-GGFG-Dxd is a drug-linker conjugate targeting antibody-drug conjugates (ADCs) with potent antitumor activity derived from the DNA topoisomerase I inhibitor Dxd. This compound utilizes a cleavable linker, DBCO-PEG4-GGFG, which enhances selective delivery of the therapeutic agent. DBCO-PEG4-GGFG-Dxd serves as a click chemistry reagent, featuring a DBCO moiety that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules, making it a valuable tool in bioconjugation applications. -
Drug-Linker Conjugates for ADC
DBCO-PEG4-Val-Cit-PAB-MMAF is a drug-linker conjugate designed for use in antibody-drug conjugates (ADCs) that combines a cleavable PEG linker with the potent tubulin polymerization inhibitor MMAF. The DBCO moiety facilitates efficient synthesis through click chemistry, specifically strain-promoted alkyne-azide cycloaddition (SPAAC), allowing for precise conjugation to azide-containing biomolecules. This reagent is essential for enhancing the therapeutic efficacy of ADCs by enabling targeted delivery of cytotoxic agents. -
Drug-Linker Conjugate for ADC
DBCO-PEG4-MMAF is a drug-linker conjugate designed for antibody-drug conjugate (ADC) applications, utilizing MMAF as a potent tubulin polymerization inhibitor. The conjugate features a cleavable linker, DBCO-PEG4, which facilitates the selective release of MMAF within target cells. DBCO-PEG4-MMAF serves as a click chemistry reagent, containing a DBCO group that efficiently engages in strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-modified molecules, making it a valuable tool for targeted therapeutics in cancer research. -
Drug-Linker Conjugates for ADC
DBCO-(PEG2-VC-PAB-MMAE)2 is a drug-linker conjugate designed for use in antibody-drug conjugates (ADCs). This compound features Monomethyl auristatin E (MMAE), a potent tubulin inhibitor, linked to a cleavable DBCO-(PEG2-VC-PAB)2 linker. The DBCO group enables efficient strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules, facilitating targeted delivery of cytotoxic agents. Its application is crucial for research in cancer therapeutics, particularly in enhancing the efficacy and selectivity of ADCs. -
Drug-Linker Conjugate For ADC
TCO-PEG4-VC-PAB-MMAE is a drug-linker conjugate designed for antibody-drug conjugate (ADC) applications. This compound features a cleavable linker (TCO-PEG4-VC-PA) that facilitates the release of the potent tubulin inhibitor MMAE upon cellular internalization. TCO-PEG4-VC-PAB-MMAE incorporates a TCO group suitable for inverse electron demand Diels-Alder (iEDDA) reactions, enabling highly specific conjugation with tetrazine-containing molecules, thus enhancing therapeutic efficacy in targeted treatments. -
Drug-Linker Conjugate for ADC
DBCO-(PEG)3-VC-PAB-MMAE is a drug-linker conjugate designed for antibody-drug conjugates (ADCs). This compound features Monomethyl auristatin E (MMAE) linked to a DBCO-(PEG)3-VC-PAB structure, facilitating targeted drug delivery in cancer research. As a click chemistry reagent, it utilizes a DBCO group that enables strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules, making it valuable in bioconjugation applications. -
Drug-Linker Conjugate for ADC
DBCO-PEG3-VC-Exatecan is a drug-linker conjugate designed for antibody-drug conjugate (ADC) applications. This compound combines the DBCO-PEG3-VC linker with Exatecan, a potent inhibitor of DNA topoisomerase I. Its structure facilitates targeted delivery of the cytotoxic agent to cancer cells, enhancing therapeutic efficacy while minimizing off-target effects. Research applications include the development of ADCs for cancer treatment, providing a strategic tool for targeted therapy and molecular oncology studies. -
Drug-Linker Conjugates for ADC
DBCO-PEG4-VA-PBD is a drug-linker conjugate designed for antibody-drug conjugate (ADC) applications. This compound utilizes the potent antitumor antibiotic Pyrrolobenzodiazepine (PBD), which is linked via a DBCO-PEG4-VA spacer. DBCO-PEG4-VA-PBD acts as a click chemistry reagent, featuring a DBCO moiety that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. This functionality supports the development of targeted therapies for cancer treatment, enhancing the efficacy of ADCs. -
Drug-Linker Conjugates for ADC
endo-BCN-PEG4-Val-Cit-PAB-MMAE is a cleavable linker specifically designed for antibody-drug conjugates (ADCs), facilitating the targeted delivery of therapeutic agents. This compound features a 4-unit polyethylene glycol (PEG) chain and incorporates a BCN group that enables efficient strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. Its versatility is highly applicable in the development of ADCs, enhancing the efficacy and specificity of cancer therapies. -
ADC Drug-Linker Conjugate
DBCO-Val-Cit-PAB-MMAE is an ADC drug-linker conjugate designed for the synthesis of antibody-drug conjugates (ADCs). It incorporates the tubulin inhibitor MMAE, which acts as a cytotoxic agent targeting rapidly dividing cells. The DBCO-Val-Cit-PAB linker features an electrophilic group, facilitating stable conjugation to antibodies and enhancing the therapeutic efficacy of ADCs in cancer research applications. -
Drug-Linker Conjugate for ADC
DBCO-PEG4-VC-PAB-DMEA-PNU-159682 is a drug-linker conjugate designed for antibody-drug conjugates (ADCs). It combines the DBCO-PEG4-VC-PAB linker with the potent cytotoxin DMEA-PNU-159682, which includes active metabolites of nemorubicin. This compound leverages click chemistry, featuring a DBCO group that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. DBCO-PEG4-VC-PAB-DMEA-PNU-159682 serves as an effective tool in targeted cancer therapy research and the development of innovative ADCs. -
Drug-Linker Conjugate for ADC
BCN-HS-PEG2(vcPABC-MMAE)2 is a drug-linker conjugate designed for antibody-drug conjugate (ADC) applications. This compound incorporates a cleavable linker and the microtubule inhibitor MMAE, facilitating targeted delivery of cytotoxic agents to cancer cells. BCN-HS-PEG2(vcPABC-MMAE)2 is vital for researchers involved in the development and synthesis of ADCs, enhancing therapeutic efficacy while minimizing systemic toxicity. -
Drug-Linker Conjugate for ADC
DBCO-β-Glu-PEG12-Exatecan serves as a drug-linker conjugate specifically designed for antibody-drug conjugates (ADCs). This compound acts as a potent inhibitor of topoisomerase I, effectively disrupting DNA replication and transcription processes. Its unique structure allows for targeted delivery in therapeutic applications, making it suitable for research in cancer treatment and other malignancies. This reagent provides a valuable tool for the development and optimization of ADC formulations. -
Drug-Linker Conjugate for ADC
DBCO-PEG4-VA-PABC-MMAE is a drug-linker conjugate designed for antibody-drug conjugates (ADCs). It features a potent tubulin inhibitor, MMAE, linked via a cleavable moiety, DBCO-PEG4-VA-PABC, facilitating targeted delivery to cancer cells. This conjugate is suitable for the synthesis of ADCs, demonstrating potential application in targeted cancer therapies by enhancing therapeutic efficacy while minimizing systemic toxicity. -
Anticancer Agent
DBCO-PEG3-GGFG-Exatecan is a drug-linker conjugate designed for use in antibody-drug conjugate (ADC) applications. This compound features the DBCO-PEG3-GGFG linker combined with Exatecan, a potent DNA topoisomerase I inhibitor. It is engineered to enhance the targeted delivery of cytotoxic agents to cancer cells, thereby improving therapeutic efficacy. DBCO-PEG3-GGFG-Exatecan is suited for research in cancer biology and the development of novel treatment strategies. -
Drug-Linker Conjugate
DBCO-PEG4-Ahx-DM1 is a drug-linker conjugate that incorporates the potent microtubulin inhibitor DM1, designed to facilitate antibody-drug conjugate (ADC) development. DM1, a maytansinoid, targets microtubules to inhibit cancer cell proliferation while minimizing systemic toxicity. The DBCO moiety in this compound allows for strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing biomolecules, enabling efficient conjugation for targeted delivery in cancer research applications. -
Drug-linker Conjugate for ADC
DBCO-PEG3-Glu-VC-PABC-MMAF is a drug-linker conjugate designed for use in antibody-drug conjugates (ADCs). It features the tubulin inhibitor MMAF linked through a cathepsin cleavable DBCO-PEG3-Glu-VC-PABC moiety, facilitating targeted delivery of the cytotoxic agent. This compound is valuable for research applications focusing on the development of ADCs, enabling studies on efficacy, mechanism of action, and therapeutic potential in cancer treatment. -
Click Reaction Agent
Mivebresib-alkyne functions as a Click Reaction Agent, facilitating the synthesis of BRD4-targeted PROTACs. This derivative of Mivebresib serves as an important tool for researchers investigating targeted protein degradation pathways and their potential therapeutic applications. Its unique alkyne functionality enables efficient conjugation reactions, enhancing the versatility of PROTAC development in chemical biology studies. -
Fluorescent Dye
Cy5-DBCO is a near-infrared fluorescent dye that features an absorption maximum at 646 nm and emission maximum at 670 nm. This compound functions as a click chemistry reagent, containing a DBCO group that readily participates in strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. It is particularly useful in bioconjugation applications, facilitating the labeling of proteins and other biomolecules for imaging and tracking studies, although it is not recommended for staining intracellular components in permeabilized cells due to potential high background. -
Orange Fluorescent Dye
DBCO-Cy3 is an orange fluorescent dye derived from the Cyanine3 fluorophore, exhibiting stable fluorescence across a pH range of 4-10. It has an excitation maximum at 555 nm and an emission maximum at 580 nm, making it suitable for various fluorescence applications. DBCO-Cy3 features rapid reaction kinetics and is compatible with standard fluorescence instruments. As a click chemistry reagent, it contains a DBCO group that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules, enabling targeted labeling and imaging in biochemical research. -
Cy5 Derivative
Sulfo-Cy5-tetrazine is a Cy5 derivative featuring a tetrazine moiety that serves as a potent click chemistry reagent. This compound exhibits fluorescence properties similar to Cy5, with excitation/emission maxima at 633/647 nm. Sulfo-Cy5-tetrazine is optimized for use in biochemical applications requiring selective labeling, enabling the visualization of biomolecules through inverse electron demand Diels-Alder reactions with trans-cyclooctene (TCO) functionalized partners. This reagent is ideal for use in various biological research contexts, including molecular imaging and assay development. -
Red Fluorescent Dye
Janelia Fluor® 646, Tetrazine is a red fluorescent dye characterized by its tetrazine moiety. This compound serves as a versatile click chemistry reagent, enabling efficient labeling through inverse electron demand Diels-Alder (iEDDA) reactions with TCO-containing molecules. Its robust fluorescent properties make JF646, Tetrazine suitable for applications in cellular imaging, facilitating the visualization of dynamic biological processes in live cells. -
Near-Infrared Fluorescent Dye
Cyanine5.5 alkyne chloride is a near-infrared fluorescent dye that exhibits excitation at 678 nm and emission at 694 nm. This alkynyl-modified compound is particularly effective for click chemistry applications, enabling efficient labeling through reactions with azides. Its properties make it suitable for a variety of biological research applications, including imaging and tracking in live cells and tissues. -
Dye Reagent
DBCO-PEG12-TCO is a dual-functional click chemistry reagent featuring both DBCO and TCO moieties. The DBCO group enables strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-bearing molecules, while the TCO moiety is capable of engaging in inverse electron demand Diels-Alder (iEDDA) reactions with tetrazine-containing compounds. This reagent is suitable for applications in bioconjugation, drug discovery, and the development of functionalized biomolecules in chemical biology research. -
BG-JQ1 Intermediate
BG-DBCO is a DBCO-conjugated benzylguanine that serves as an essential intermediate for synthesizing BG-JQ1. This compound forms a complex with SNAP-E3 fusion protein and Ligand-N3, facilitating targeted applications in cellular research. BG-JQ1, derived from the conjugation of BG-DBCO with JQ1-N3-C10, has demonstrated potent inhibitory effects on the growth of small cell carcinoma of the adrenocortical gland when administered alongside SIAH1-SN mRNA. This reagent is invaluable for studies aimed at understanding and targeting cancer cell proliferation pathways. -
Dye
Alkyne MegaStokes dye 608 is a versatile fluorescent dye that enables effective labeling and visualization of biological samples. This dye is crucial for observing cell structures, tracking biomolecules, and evaluating various cellular functions. It can distinguish cell types, detect biomolecules, and study tissue pathology, making it valuable for both basic scientific research and clinical diagnostics. Additionally, Alkyne MegaStokes dye 608 finds applications in functional textile processing, food pigments, and dye-sensitized solar cells. -
Dye
Alkyne MegaStokes dye 735 is a multifunctional dye that serves as a critical tool for biological experiments. It facilitates the observation and analysis of cellular structures, tracking of biomolecules, and evaluation of cell functions. This dye is valuable for distinguishing cell types, detecting biomolecules, studying tissue pathology, and monitoring microorganisms. Its diverse applications extend from fundamental scientific research to clinical diagnostics and emerging fields such as functional textiles and dye-sensitized solar cells. -
Click Chemistry Reagent
Trisulfo-Cy5-Alkyne is a versatile click chemistry reagent featuring an alkyne group suitable for copper-catalyzed reactions. This compound exhibits near-infrared (NIR) fluorescence, making it ideal for biological imaging applications. Trisulfo-Cy5-Alkyne is primarily used in the conjugation of biomolecules, facilitating studies in cellular localization and molecular interactions within complex biological systems. -
Click Chemistry Reagent
Trisulfo-Cy5.5-Alkyne is a click chemistry reagent featuring an azide functional group, enabling its use in copper-catalyzed click reactions. This compound exhibits near-infrared (NIR) fluorescence, making it a valuable tool for various biological imaging applications. It is particularly useful for labeling biomolecules in live-cell studies, facilitating the visualization of cellular processes and interactions. -
Fluorescence Dye
Sulfo-Cy3-Tetrazine is a water-soluble cyanine fluorescence dye that features a tetrazine group for click chemistry applications. It functions through an inverse electron demand [4+2] cycloaddition reaction with trans-cyclooctene or other strained olefins, facilitating specific labeling and detection of biomolecules. This reagent is ideal for various applications in fluorescence microscopy, imaging, and other biological assays requiring precise and efficient molecular tagging. -
Click Chemistry Reagent
Sulfo-Cy5-Methyltetrazine is a click chemistry reagent characterized by a methyltetrazine functionality. This compound serves as a fluorophore linker for trans-cyclooctene-based labeling applications, facilitating the visual tracking of biomolecules. It exhibits excellent stability at physiological pH and demonstrates high reactivity towards cyclooctene, making it suitable for a variety of biological and biochemical research applications, including target identification and protein labeling. -
Click Chemistry Reagent
Sulfo-Cy3-Methyltetrazine is a click chemistry reagent characterized by its methyltetrazine functionality and a water-soluble fluorescent dye. It exhibits excellent stability under physiological pH conditions, making it suitable for various biological applications. This reagent effectively couples with trans-cyclooctene and shows a high reactivity towards cyclooctene, enabling precise labeling and detection in live-cell imaging and other bioorthogonal applications. -
Fluorescent Probe
Alkyne-probe 1 is a fluorescent probe designed for click chemistry applications. Featuring an alkyne group, this reagent is capable of undergoing copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. Its ability to facilitate efficient labeling makes it a valuable tool for studying biomolecular interactions and visualizing cellular processes in various research applications.
