Catalog No.
Product Name
Application
Product Information
Citations
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BET inhibitor
JQ1-TCO (JQ1-trans-cyclooctene) is a derivative of JQ1, a BET inhibitor, modified for click chemistry applications. It serves as a molecular probe for in vitro and in vivo studies. -
Drug-Linker Conjugate
TCO-PEG3-Glu-Val-Cit-PABC-MMAF is a drug-linker conjugate designed for targeted delivery in antibody-drug conjugate (ADC) applications. It incorporates a trans-cyclooctene (TCO) moiety for efficient click chemistry attachment, a polyethylene glycol (PEG) spacer for solubility enhancement, and a cleavable linker (Glu-Val-Cit) that releases the potent cytotoxic agent MMAF upon internalization. This reagent is ideal for advancing research in targeted cancer therapeutics and ADC development. -
Drug-Linker Conjugate For ADC
TCO-PEG4-VC-PAB-MMAE is a drug-linker conjugate designed for antibody-drug conjugate (ADC) applications. This compound features a cleavable linker (TCO-PEG4-VC-PA) that facilitates the release of the potent tubulin inhibitor MMAE upon cellular internalization. TCO-PEG4-VC-PAB-MMAE incorporates a TCO group suitable for inverse electron demand Diels-Alder (iEDDA) reactions, enabling highly specific conjugation with tetrazine-containing molecules, thus enhancing therapeutic efficacy in targeted treatments. -
Dye Reagent
DBCO-PEG12-TCO is a dual-functional click chemistry reagent featuring both DBCO and TCO moieties. The DBCO group enables strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-bearing molecules, while the TCO moiety is capable of engaging in inverse electron demand Diels-Alder (iEDDA) reactions with tetrazine-containing compounds. This reagent is suitable for applications in bioconjugation, drug discovery, and the development of functionalized biomolecules in chemical biology research. -
Fluorochrome Dye
Coumarin-C2-TCO is a fluorochrome dye that incorporates a TCO group, enabling it to participate in inverse electron demand Diels-Alder (iEDDA) reactions with tetrazine-tagged molecules. This reactivity allows for specific and efficient labeling in various biological applications, including live cell imaging and protein tagging. The versatility of Coumarin-C2-TCO makes it a valuable tool for studying dynamic cellular processes and enhancing fluorescent assay sensitivity. -
Fluorochrome Dye
Coumarin-PEG3-TCO is a fluorochrome dye that incorporates three PEG units to enhance solubility and stability. Its TCO group facilitates an inverse electron demand Diels-Alder reaction (iEDDA) with tetrazine-bearing molecules, making it ideal for bioorthogonal labeling applications. This reagent is particularly useful in fluorescence microscopy and tracking cellular processes in live cells. -
Fluorochrome Dye
Coumarin-PEG2-TCO is a fluorescent dye that features a coumarin backbone modified with two PEG units. It utilizes a trans-cyclooctene (TCO) group to engage in an inverse electron demand Diels-Alder (iEDDA) reaction with tetrazine-containing compounds. This compound is valuable in biological imaging applications and has potential uses in the development of targeted fluorescent probes for live-cell imaging and other bioconjugation strategies. -
Dye
Sulfo-Cy5-TCO is a water-soluble fluorescent dye that incorporates a trans-cyclooctene (TCO) moiety, facilitating rapid and efficient click chemistry reactions with tetrazines and methyltetrazines. This reagent is designed for use in bioconjugation applications, offering high reactivity and speed that enhances labeling efficiency in various biological experiments. Its unique properties make Sulfo-Cy5-TCO valuable for researchers in fields such as cellular imaging, biomolecule tracking, and targeted drug delivery. -
Fluorescent Dye
BP Fluor 488 TCO is a fluorescent dye that participates in the inverse-electron demand Diels-Alder cycloaddition reaction, reacting rapidly and selectively with tetrazines to form stable covalent linkages. This biocompatible reaction occurs without the need for copper catalysts or elevated temperatures, exhibiting an exceptionally high reaction rate constant (k > 800 M-1 s-1). BP Fluor 488 TCO is ideal for applications in bioorthogonal labeling, visualization, and tracking of biomolecules in live cells and various biological studies. -
ADC Linker
DBCO-PEG3-TCO is a non-cleavable linker designed for the synthesis of antibody-drug conjugates (ADCs), featuring a 3-unit polyethylene glycol (PEG) spacer. This reagent facilitates click chemistry through its dibenzocyclooctyne (DBCO) moiety, enabling strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-functionalized compounds. Additionally, the TCO group supports inverse electron demand Diels-Alder (iEDDA) reactions with tetrazine-containing molecules, making DBCO-PEG3-TCO a versatile tool for advancing ADC development in therapeutic research. -
PROTAC Linker
TCO-PEG4-DBCO is a versatile PROTAC linker known for its ability to facilitate the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features a DBCO moiety that enables strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing compounds, while the TCO component allows for inverse electron demand Diels-Alder (iEDDA) reactions with tetrazine derivatives. TCO-PEG4-DBCO finds applications in the development of antibody-drug conjugates (ADCs), enhancing the precision and efficacy of targeted therapeutics. Its unique chemical properties make it a valuable tool for researchers in chemical biology and drug development. -
ADC Linker
TCO-SS-amine is a cleavable linker designed for the synthesis of antibody-drug conjugates (ADCs). Featuring a TCO group, this reagent facilitates the inverse electron demand Diels-Alder reaction (iEDDA) with tetrazine-containing molecules. Its selective and efficient coupling capabilities make TCO-SS-amine a valuable tool in ADC development, enabling targeted delivery of therapeutic agents in cancer research and drug discovery applications. -
Azide Compound
TCO-PEG2-Sulfo-NHS ester-EDC Urea is a click chemistry reagent featuring an azide group, designed for selective labeling of primary amine-containing biomolecules. The compound incorporates a PEG linker and a sulfo-NHS ester moiety, enhancing solubility in aqueous buffers, facilitating its utility in bioconjugation applications. It enables the covalent attachment of TCO moieties to proteins, antibodies, and other macromolecules, while participating in inverse electron demand Diels-Alder (iEDDA) reactions with tetrazine-containing partners. This reagent is suitable for various research applications, including protein labeling and targeted drug delivery studies. -
ADC Linker
TCO-GK-PEG4-NHS ester is an ADC linker that facilitates the synthesis of [18F]AlF-NOTA-Tz-TCO-GK-2Rs15d, which exhibits high affinity and immunoreactivity for the HER2 target. This compound features a TCO group that participates in inverse electron demand Diels-Alder (iEDDA) click chemistry reactions with tetrazine-containing molecules, allowing for precise bioconjugation applications in targeted therapies. It is suitable for research involving antibody-drug conjugates and the development of advanced molecular imaging techniques. -
Click Chemistry Reagent
TCO-PEG3-maleimide is a click chemistry reagent that facilitates the efficient conjugation of trans-cyclooctene (TCO) moieties to thiol-containing molecules, including antibodies and cysteine-containing peptides. Through a rapid and selective reaction with thiol groups, this compound is valuable for a variety of bioconjugation applications. Its unique properties enable researchers to explore novel therapeutic strategies and enhance the development of bioconjugates in chemical biology. -
ADC/PROTAC Linker
TCO-PEG12-NHS ester is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras) and antibody-drug conjugates (ADCs). This cleavable linker facilitates the conjugation of therapeutics, enabling targeted degradation of specific proteins via the ubiquitin-proteasome pathway. Its unique properties make it suitable for advancing research in targeted therapies and optimizing drug delivery systems. -
Click Chemistry Reagent
TCO-NHS Ester (axial) is a versatile click chemistry reagent primarily used for site-specific labeling in amine reactions. The compound features TCO groups that participate in inverse electron demand Diels-Alder (iEDDA) reactions with tetrazine-containing molecules. It is valuable in bioconjugation and molecular imaging applications, enabling researchers to construct complex biomolecular structures. -
ADC Linker
Gly-Gly-Gly-PEG3-TCO is a polyethylene glycol (PEG) linker featuring a TCO moiety, primarily utilized in the synthesis of antibody-drug conjugates (ADCs). This compound facilitates click chemistry through its ability to participate in inverse electron demand Diels-Alder (iEDDA) reactions with tetrazine-containing molecules. Its application in ADC development enhances targeted delivery and therapeutic efficacy in the treatment of various diseases. -
ADC Linker
TCO-PEG3-Biotin is a cleavable linker designed for antibody-drug conjugate (ADC) synthesis, featuring a three-unit polyethylene glycol (PEG) backbone. This compound includes a trans-cyclooctene (TCO) moiety that facilitates click chemistry through an inverse electron demand Diels-Alder (iEDDA) reaction with tetrazine-containing molecules. TCO-PEG3-Biotin is valuable in conjugating biomolecules, enabling targeted drug delivery and enhancing therapeutic efficacy in various biological research applications. -
PSMA Inhibitor
TcO-ABX474 is a potent inhibitor of prostate-specific membrane antigen (PSMA), exhibiting a Kd value of 6.1 nM. It effectively inhibits the growth and metastasis of prostate cancer cells, making it a valuable tool for research in prostate cancer biology. This compound is suitable for studies investigating PSMA-mediated pathways and the development of targeted therapies for prostate cancer. -
PEGylated Derivative
DSPE-PEG2000-TCO is a PEGylated derivative that functions as a coupling partner in click chemistry through a reverse electron-demand Diels-Alder reaction. This compound facilitates the formation of covalent linkages with tetrazine-modified biomolecules, enhancing the stability of lipid nanoparticles (LNPs) while promoting efficient mRNA encapsulation. It plays a critical role in the development of EGFR-targeted and APN-targeted mRNA-loaded LNPs, supporting receptor-mediated endocytosis, effective mRNA delivery, and intestinal epithelial transcytosis in various research applications. -
PROTAC Linkers
TCO-PEG8-NHS ester is a PEG-based linker designed for use in the synthesis of PROTACs (proteolysis targeting chimeras). This compound facilitates the conjugation of target proteins with E3 ligases, enabling targeted degradation of proteins thought unsuitable for classical small-molecule approaches. It is a valuable tool for researchers investigating protein regulation, cellular signaling pathways, and therapeutic interventions through targeted protein degradation. -
PROTAC Linker
TCO-amine (hydrochloride) is an alkyl chain-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound contains a TCO moiety, enabling it to participate in inverse electron demand Diels-Alder (iEDDA) reactions with tetrazine-containing molecules. TCO-amine (hydrochloride) serves as a crucial tool in targeted protein degradation research, facilitating the development of novel therapeutic agents. -
PROTAC Linkers
TCO-PEG9-maleimide is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). It facilitates the conjugation of targeting moieties and E3 ligase recruiting units, enabling the effective degradation of selected proteins. This linker is particularly valuable in chemical biology and drug discovery research, where targeted protein degradation mechanisms are being explored for therapeutic development. -
PROTAC Linkers
TCO-PEG6-amine is a PEG-derived linker designed for use in the synthesis of PROTAC (Proteolysis Targeting Chimera) compounds. This linker facilitates the development of bifunctional molecules to selectively degrade target proteins via the ubiquitin-proteasome system. Its unique structure enables effective conjugation with other moieties, contributing to research applications in targeted protein degradation and molecular biochemistry. -
PROTAC Linker
TCO-PEG4-NHS ester is a PEG-based linker utilized in the synthesis of PROTACs. Its primary mechanism involves click chemistry, specifically the inverse electron demand Diels-Alder (iEDDA) reaction with tetrazine-containing molecules. TCO-PEG4-NHS ester facilitates targeted protein degradation, making it a valuable tool for research applications in pharmacology and molecular biology, particularly in the development of novel therapeutics. -
PROTAC Linker
TCO-NHS ester is an alkyl/ether-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). As a click chemistry reagent, it features a TCO group capable of undergoing an inverse electron demand Diels-Alder (iEDDA) reaction with tetrazine-containing molecules. This property makes TCO-NHS ester a valuable tool for the construction of complex bioconjugates and the development of targeted protein degradation strategies in chemical biology research. -
PROTAC Linkers
TCO-OH is an alkyl chain-based PROTAC linker designed to facilitate the synthesis of proteolysis-targeting chimeras (PROTACs). This compound plays a critical role in the creation of targeted therapies by linking E3 ligases to specific proteins for degradation. Its application is essential in the field of targeted protein degradation research, enabling the exploration of new therapeutic strategies in various diseases. -
PROTAC Linker
TCO-PEG3-amine is a polyethylene glycol (PEG)-based linker designed for use in proteolysis-targeting chimeras (PROTACs). This compound facilitates the synthesis of PROTACs, enabling targeted degradation of specific proteins within cells. Its unique structure promotes solubility and stability, making it a valuable tool in chemical biology and therapeutic research applications. -
PROTAC Linkers
TCO-PEG2-amine is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the targeted degradation of specific proteins through the ubiquitin-proteasome system, making it a valuable tool for chemical biology research. Its flexibility and solubility contribute to improved efficacy in the development of innovative therapeutic strategies targeting various diseases. -
PROTAC Linkers
TCO-PEG6-NHS ester is a PEG-based linker designed for use in the synthesis of Proteolysis Targeting Chimeras (PROTACs). This intermediary compound facilitates the conjugation of targeting ligands to E3 ligases, thereby enhancing the efficiency of targeted protein degradation. Its versatile applications in drug discovery make it a valuable tool for researchers investigating protein modulation and degradation pathways. -
PROTAC Linker
N-(Mal-PEG6)-N-bis(PEG7-TCO) is a PEG-based linker specifically designed for PROTAC synthesis. This compound features a TCO moiety that facilitates the inverse electron demand Diels-Alder reaction (iEDDA) with tetrazine-containing molecules, enabling effective targeting and degradation of proteins. It is widely used in chemical biology to create novel therapeutics and to study protein interactions and degradation pathways. -
PROTAC Linker
TCO4-PEG2-Maleimide is a versatile PROTAC linker that facilitates targeted protein degradation pathways. Its structural components, including TCO and Maleimide moieties, enable efficient "click" chemistry interactions with tetrazine groups and thiol groups, as well as "mercapto-acrylamide" reactions. This reagent is a valuable tool for researchers developing bifunctional molecules for targeted degradation studies in various biological systems. -
PROTAC Linkers
TCO-PEG3-NHS ester is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the conjugation of target proteins to E3 ligase, promoting ubiquitination and subsequent degradation. Its versatile structure makes it a valuable tool in chemical biology for the development of targeted protein degradation strategies. -
PROTAC Linkers
TCO-PEG4-biotin is a PEG-based PROTAC linker designed to facilitate the construction of PROTACs. This compound enhances the solubility and stability of the resulting bifunctional molecules, enabling targeted protein degradation. Its incorporation into PROTACs allows for selective modulation of target proteins, making it a valuable tool in chemical biology and therapeutic research applications. -
PROTAC Linkers
TCO-PEG2-Sulfo-NHS ester is a PEGylated PROTAC linker that facilitates the synthesis of proteolysis-targeting chimeras (PROTACs). This compound enables efficient conjugation of targeting ligands to E3 ligases, enhancing cellular degradation of specific proteins. Its utility in drug discovery and development makes it a valuable tool for researchers investigating targeted protein degradation strategies. -
PROTAC Linkers
TCO-PEG8-TFP ester is a PEG-based linker designed for the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the conjugation of target proteins to E3 ligases, enhancing protein degradation processes. Its structural properties allow for improved solubility and cellular uptake, making it a valuable tool in targeted protein degradation research and drug discovery applications. -
PROTAC Linkers
TCO-PEG3-alcohol is a PEG-based linker specifically designed for PROTAC synthesis, functioning primarily through the inverse electron demand Diels-Alder (iEDDA) reaction. This compound features a TCO moiety that enables efficient coupling with tetrazine-conjugated molecules, facilitating the development of targeted protein degradation strategies. Its use in research applications enhances the exploration of protein function and regulation in various biological pathways. -
PROTAC Linker
TCO4-PEG3-Maleimide is a PROTAC linker designed for targeted protein degradation applications. It features TCO and Maleimide functional groups, enabling precise "click" reactions with tetrazine and thiol compounds, or "mercapto-acrylamide" reactions. This compound facilitates the development of innovative therapeutic modalities by promoting effective protein-interaction dynamics in chemical biology research. -
PROTAC Linkers
(R)-TCO-OH is a click chemistry reagent designed for use as a linker in PROTAC (proteolysis-targeting chimeras) synthesis. This compound features a trans-cyclooctene (TCO) moiety, which allows it to undergo an inverse electron-demand Diels-Alder (iEDDA) reaction with tetrazine-containing partners, facilitating selective protein degradation. Its application is critical in the development of targeted protein degradation strategies for various biological and therapeutic research areas. -
PROTAC Linkers
TCO-PEG8-amine is a polyethylene glycol (PEG)-based linker designed for the synthesis of PROTACs (proteolysis targeting chimeras). It facilitates the formation of bifunctional molecules by covalently linking target proteins to E3 ligases, enabling targeted protein degradation. This reagent is essential for researchers exploring innovative therapeutic strategies in cancer, neurodegenerative diseases, and other pathologies through targeted modulation of protein levels. -
PROTAC Linkers
TCO-PEG3-amide-C3-triethoxysilane is a PEG-based linker designed for use in the synthesis of PROTAC (Proteolysis Targeting Chimera) molecules. Its triethoxysilane group facilitates conjugation to various surfaces or substrates, enhancing the development of targeted protein degradation strategies. This compound serves as a crucial tool for researchers investigating targeted therapies and protein modulation. -
PROTAC Linkers
TCO-PEG3-TCO is a PEG-based PROTAC linker designed to facilitate the synthesis of proteolysis-targeting chimeras (PROTACs). This compound enhances the stability and solubility of PROTACs while effectively linking E3 ligases to target proteins, thereby promoting targeted protein degradation. Its applications are vital in research focused on elucidating protein functions and developing novel therapeutic strategies in cancer and other diseases. -
PROTAC Linker
TCO-PEG4-acid is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound serves as an effective spacer, facilitating the coupling of E3 ligase recruiters and target proteins, thereby enhancing the degradation of specific proteins in cellular assays. Its application in PROTAC development supports investigations into targeted protein degradation and therapeutic strategies in various diseases. -
PROTAC Linkers
TCO-PEG6-acid is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). It features a TCO (Trans-Cyclooctene) moiety that enables efficient ligation with a specific cyclopropene partner, facilitating the selective degradation of target proteins. This compound is essential for researchers developing targeted protein degradation strategies and studying cellular processes involving controlled protein levels. -
PROTAC Linkers
TCO-PEG8-acid is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound features a TCO (trans-cyclooctene) moiety, enabling it to participate in inverse electron demand Diels-Alder reactions with tetrazine-conjugated molecules. Its utility in click chemistry makes it a valuable tool for researchers aiming to develop innovative therapeutics targeting specific proteins for degradation. -
PROTAC Linkers
TCO-PEG24-NHS ester is a PEG-based linker designed for PROTAC synthesis, facilitating the creation of bifunctional molecules for targeted protein degradation. This compound features a TCO moiety, enabling it to engage in inverse electron demand Diels-Alder (iEDDA) reactions with Tetrazine-containing partners. It serves as a valuable tool for researchers exploring innovative therapeutic strategies in chemical biology and drug discovery. -
PROTAC Linkers
TCO-PEG8-TCO is a PEG-based PROTAC linker designed for the synthesis of protein-targeting chimeras. This linker facilitates the conjugation of E3 ligase recruiters and protein-targeting moieties, enhancing the stability and efficacy of PROTAC compounds. It is instrumental in advancing research in targeted protein degradation and drug discovery applications. -
PROTAC Linkers
TCO-PEG4-amine is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (proteolysis targeting chimeras). This compound serves as a versatile building block to facilitate the recruitment of E3 ligases for targeted protein degradation, enabling the modulation of protein levels in biological systems. Its application in the development of PROTACs supports research into therapeutic strategies for various diseases by allowing precise control over protein function and turnover.
