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TCS 21311

JAK3 inhibitor

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Catalog No. A15365

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
TCS 21311 10mg A15365-10
$190.00
TCS 21311 50mg A15365-50
$790.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

TCS 21311 is a potent JAK3 inhibitor (IC50 = 8 nM). TCS 21311 is selective for JAK3 over JAK1, JAK2 and Tyk 2 (IC50 values are 1017, 2550 and 8055 nM respectively).

TCS 21311

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Chemical Information

Catalog Num A15365
Actions Inhibitor
M. Wt 526.51
Formula C27H25F3N4O4
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1260181-14-3
Synonyms TCS21311, TCS-21311
SMILES CC(C)(C(=O)N1CCN(CC1)C2=CC(=C(C=C2)C(F)(F)F)C3=C(C(=O)NC3=O)C4=CNC5=CC=CC=C54)O

Biological Activity

Description
TCS 21311 is a potent JAK3 inhibitor (IC50 = 8 nM). TCS 21311 is selective for JAK3 over JAK1, JAK2 and Tyk 2 (IC50 values are 1017, 2550 and 8055 nM respectively).

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18.99 mL 94.96 mL 189.93mL
0.5 mM 3.8 mL 18.99 mL 37.99 mL
1 mM 1.9 mL 9.5 mL 18.99 mL
5 mM 0.38 mL 1.9 mL 3.8 mL

*The above data is based on the productmolecular weight 526.51. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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