TEAD ligand-Linker Conjugate 1

Catalog No.: A84655
Target Protein Ligand-Linker Conjugate
TEAD ligand-Linker Conjugate 1 is a synthetic ligand-linker conjugate designed for the development of PROTACs, specifically for creating PROTAC TEAD degrader-2, which demonstrates potent degradation of the TEAD1 protein. This compound is pivotal for anti-cancer research, facilitating targeted protein degradation to study TEAD1’s role in cancer progression and therapeutic responses. Its application in PROTAC technology presents opportunities for innovative approaches in cancer treatment and molecular biology research.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionTEAD ligand-Linker Conjugate 1 is a synthetic ligand-linker conjugate designed for the development of PROTACs, specifically for creating PROTAC TEAD degrader-2, which demonstrates potent degradation of the TEAD1 protein. This compound is pivotal for anti-cancer research, facilitating targeted protein degradation to study TEAD1’s role in cancer progression and therapeutic responses. Its application in PROTAC technology presents opportunities for innovative approaches in cancer treatment and molecular biology research.
Product Information
Catalog NumA84655
FormulaC31H31ClF2N2O5
Molecular Weight585.04
CAS Number2918762-34-0
SMILESO=C(C1=[C@@]([C@@]2=C3[C@H](C)[C@](C4=CC=CC=C4)(CN[C@@H]5CC[C@H](CC5)C(O)=O)OC3=CC(F)=C2Cl)C(F)=C(OC)C=C1)N
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