Catalog No.
Product Name
Application
Product Information
Citations
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Target Protein Ligand-Linker Conjugates
K-Ras ligand-Linker Conjugate 6 is designed to selectively target K-Ras through its ligand-recruiting moiety, while featuring a PROTAC linker that facilitates the recruitment of E3 ligases such as VHL, CRBN, MDM2, and IAP. This compound is instrumental in the synthesis of PROTAC K-Ras Degrader-1, a potent degrader that demonstrates at least 70% degradation efficacy in SW1573 cells. Its unique properties make it an essential tool for researchers studying K-Ras signaling and targeted protein degradation in cancer biology. -
Target Protein Ligand-Linker Conjugates
BMS-1166-N-piperidine-CO-N-piperazine dihydrochloride is a compound designed for the synthesis of Protein Targeting Chimeras (PROTACs) targeting the PD-1/PD-L1 immune checkpoint. It features a ligand that facilitates binding to PD-1/PD-L1 and includes a PROTAC linker for degradation of target proteins. This compound can be utilized in the development of PROTAC PD-1/PD-L1 degrader-1, which effectively inhibits PD-1/PD-L1 interactions with an IC50 of 39.2 nM, making it a valuable tool for cancer immunotherapy research. -
Target Protein Ligand-Linker Conjugates
Desmorpholinyl Quizartinib-PEG2-COOH is a conjugate designed for targeted protein degradation, specifically targeting the FLT-3 receptor. This compound incorporates a FLT-3 ligand and a PEG-based PROTAC linker, facilitating the synthesis of PROTAC FLT-3 degrader 1, which effectively degrades FLT-3 internal tandem duplication (ITD) variants with an IC50 of 0.6 nM. This reagent is valuable for research applications focusing on targeted therapy and protein degradation mechanisms in hematological malignancies. -
Target Protein Ligand-Linker Conjugates
FAK ligand-Linker Conjugate 1 is designed to target Focal Adhesion Kinase (FAK) using a PROTAC linker that recruits E3 ligases, including VHL, CRBN, MDM2, and IAP. This compound facilitates the targeted degradation of proteins through the PROTAC mechanism. Its primary applications include studies in targeted protein degradation and the modulation of FAK-related signaling pathways in various biological contexts. -
Target Protein Ligand-Linker Conjugates
K-Ras ligand-Linker Conjugate 5 is designed to target the K-Ras protein through a ligand and incorporates a PROTAC linker that facilitates the recruitment of E3 ligases, including VHL, CRBN, MDM2, and IAP. This compound serves as a vital component in the synthesis of PROTAC K-Ras Degrader-1, a robust degrader that demonstrates ≥70% degradation efficacy in SW1573 cells. Its application in targeted protein degradation research makes it a valuable tool for investigating K-Ras-related pathways in oncology. -
Target Protein Ligand-Linker Conjugates
K-Ras ligand-Linker Conjugate 3 is designed to selectively target K-Ras through its ligand, combined with a PROTAC linker that facilitates the recruitment of E3 ligases such as VHL, CRBN, MDM2, and IAP. This reagent is instrumental in the development of PROTAC-based degraders, particularly in the synthesis of PROTAC K-Ras Degrader-1, which demonstrates significant degradation efficacy of ≥70% in SW1573 cells. This compound is essential for research applications in targeted protein degradation and cancer therapeutics involving K-Ras. -
Target Protein Ligand-Linker Conjugate
USP7 Ligand-Linker Conjugates 1 is a targeted protein ligand-linker conjugate designed to bind to the deubiquitinating enzyme USP7. This compound incorporates a specific USP7 ligand and a PROTAC linker that facilitates the recruitment of E3 ligases for targeted protein degradation. It serves as a crucial component in the synthesis of PROTAC USP7 Degrader-1, enabling researchers to investigate the functional role of USP7 in cellular processes and its potential as a therapeutic target. -
Target Protein Ligand-Linker Conjugate
(Rac)-PROTAC PARP/EGFR ligand 1 is a target protein ligand-linker conjugate that features ligands for both PARP and EGFR, along with a PROTAC linker to facilitate the recruitment of E3 ligases, including VHL, CRBN, MDM2, and IAP. This reagent is instrumental in the advancement of targeted protein degradation strategies in research, enabling the synthesis of DP-C-4, a CRBN-based dual PROTAC designed for the simultaneous degradation of EGFR and PARP. Its application in drug discovery highlights its utility in elucidating the roles of these critical proteins in cancer biology. -
Target Protein Ligand-Linker Conjugates
K-Ras ligand-Linker Conjugate 2 is designed to specifically target K-Ras by integrating a selective ligand with a PROTAC linker that facilitates the recruitment of E3 ligases, including VHL, CRBN, MDM2, and IAP. This conjugate serves as a critical precursor for the synthesis of PROTAC K-Ras Degrader-1, demonstrating significant biological activity by achieving ≥70% degradation efficiency in SW1573 cancer cells. It is a valuable tool for research focused on protein degradation and therapeutic strategies for K-Ras-driven cancers. -
Target Protein Ligand-Linker Conjugates
BMS-1166-N-piperidine-CO-N-piperazine serves as a targeted ligand-linker conjugate for the PD-1/PD-L1 immune checkpoint pathway. This compound is designed to facilitate the synthesis of a PROTAC PD-1/PD-L1 degrader, exhibiting potent inhibition of the PD-1/PD-L1 interaction with an IC50 value of 39.2 nM. Its applications are particularly relevant in cancer research, where modulating immune checkpoint pathways is critical for therapeutic intervention and study of immune evasion mechanisms. -
Target Protein Ligand-Linker Conjugates
K-Ras ligand-Linker Conjugate 1 is designed to target the K-Ras protein through a specific ligand, while also incorporating a PROTAC linker that facilitates the recruitment of E3 ligases such as VHL, CRBN, MDM2, and IAP. This reagent is essential for the synthesis of PROTAC K-Ras Degrader-1, a potent degrader that demonstrates greater than 70% degradation efficacy in SW1573 cells. It serves as a valuable tool for researchers investigating K-Ras-related pathways and exploring targeted protein degradation strategies. -
Target Protein Ligand-Linker Conjugates
K-Ras ligand-Linker Conjugate 4 functions as a targeted protein ligand-linker conjugate designed for K-Ras. This compound incorporates a ligand to effectively recruit K-Ras and a PROTAC linker that interacts with E3 ligases such as VHL, CRBN, MDM2, and IAP. It serves as a synthetic precursor for PROTAC K-Ras Degrader-1, demonstrating significant biological activity with at least 70% degradation efficacy in SW1573 cells. This conjugate is essential for research into targeted protein degradation and the modulation of K-Ras-related pathways. -
Target Protein Ligand-Linker Conjugates
DDR1 ligand 1-piperidine is a target protein ligand and linker conjugate designed for use in the development of PROTACs targeting DDR1. This compound facilitates the synthesis of DDR1 degrader-1, enabling research into targeted protein degradation and modulation of DDR1-related signaling pathways. Its application is crucial for studies exploring the therapeutic potential of DDR1 inhibition in various disease models. -
Target Protein Ligand-Linker Conjugates
FAK ligand-2-C6-amine is a target protein ligand-linker conjugate that incorporates a focal adhesion kinase (FAK) ligand with a PROTAC linker. This compound effectively recruits E3 ligases, facilitating the targeted degradation of specific proteins. FAK ligand-2-C6-amine is valuable in research applications focused on protein regulation and cellular signaling pathways, and it can be utilized in the synthesis of BSJ-04-146, a compound of interest in cancer research. -
Conjugate
Ahx-DM1 is a versatile conjugate designed for the targeted delivery of therapeutic, diagnostic, or labeling agents. By facilitating effective conjugation with proteins or peptides, this compound enhances the specificity and efficacy of treatments in chemical research. Its applications extend to areas such as drug development and imaging, making it an essential tool for advancing biomedical studies and experimental therapies. -
Target Protein Ligand-Linker Conjugate
Remodelin-C6-COOH is a synthesized ligand-linker conjugate designed for conjugation with target proteins. This compound facilitates the synthesis of NP1192, a potent NAT10 PROTAC degrader known for its anti-tumor activity. Remodelin-C6-COOH serves as an essential tool in the development of targeted protein degradation strategies for cancer research. -
Target Protein Ligand-Linker Conjugates
SMARCA2/4 Ligand-Linker Conjugate 2 is a specialized ligand-linker conjugate designed for targeting SMARCA2 and SMARCA4 proteins. This compound facilitates the synthesis of Proteolysis Targeting Chimeras (PROTACs), specifically enabling the development of AU-15330. It is a valuable tool in chemical biology for studying protein degradation pathways and investigating the functional roles of SMARCA family proteins in various cellular processes. -
Target Protein Ligand-Linker Conjugate
JQ-1 (carboxylic acid)-NH-C8-COOH is a synthetic linker designed for conjugation with target proteins. This compound facilitates the synthesis of JQ1-S(GlcNAc)Cq, a bifunctional degrader that exhibits significant anti-tumor activity through its Sugar-Coated PROTAC mechanism. It serves as a valuable tool in chemical research focused on targeted protein degradation and cancer biology applications. -
Target Protein Ligand-Linker Conjugate
AZD9496-O-C3-O-C3-O-C-acid is a targeted protein ligand-linker conjugate that includes a ligand specific for estrogen receptor alpha (ERα) and a PROTAC linker designed to recruit E3 ligases. This compound facilitates the development of PROTAC AZ'6421, enabling researchers to investigate targeted protein degradation pathways. It is applicable in studies focusing on hormone receptor modulation and protein regulation in cellular contexts. -
PROTAC E3 Ligases and Linkers
Adamantane-Butyl alcohol serves as a crucial linker for PROTACs targeting E3 ligases, specifically in the degradation of the CDK8-cyclin C complex. This compound facilitates targeted protein degradation, thereby enhancing the modulation of cellular processes and offering a strategic approach in research applications such as cancer biology and therapeutic development. Its selective and persistent nature makes it an integral component in the design of novel protein degraders. -
Target Protein Ligand-Linker Conjugates
BRAF ligand-Linker Conjugate 1 is a compound designed to target the BRAF protein through a ligand-linker approach. It serves as a crucial precursor for the synthesis of PROTAC CST905, facilitating targeted protein degradation. This reagent is applicable in studies focused on BRAF-related signaling pathways and therapeutic interventions for diseases associated with BRAF mutations. -
Target Protein Ligand-Linker Conjugate
TEAD ligand-Linker Conjugate 1 is a synthetic ligand-linker conjugate designed for the development of PROTACs, specifically for creating PROTAC TEAD degrader-2, which demonstrates potent degradation of the TEAD1 protein. This compound is pivotal for anti-cancer research, facilitating targeted protein degradation to study TEAD1’s role in cancer progression and therapeutic responses. Its application in PROTAC technology presents opportunities for innovative approaches in cancer treatment and molecular biology research. -
Conjugate
Ahx-DM1 TFA is a conjugate designed for the covalent attachment of proteins or peptides to therapeutic, diagnostic, or labeling agents. This compound facilitates the targeted delivery of payloads in biological applications, enhancing the efficacy of treatments. Its structural properties enable effective conjugation, making it suitable for research in drug development and protein engineering. -
Target Protein Ligand-Linker Conjugates Chemical
BRD4 ligand-Linker Conjugate 1 is a ligand-linker conjugate specifically designed for targeting the BRD4 protein. This compound plays a crucial role in the synthesis of Proteolysis Targeting Chimeras (PROTACs), facilitating targeted protein degradation. Its application is instrumental in studying BRD4-related signaling pathways and advancing drug discovery efforts in cancer and other diseases associated with epigenetic dysregulation. -
Ligand-Linker Conjugate
N-Descyclopropanecarbaldehyde Olaparib suberic acid is a ligand-linker conjugate designed for the synthesis of DDO3602. This compound functions as a crucial intermediate, facilitating the development of targeted therapeutics that leverage olaparib’s mechanism of action. Its versatility makes it relevant for applications in drug discovery and conjugation chemistry in the context of cancer research.
