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NHE3 inhibitor

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Catalog No. A14011

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
Tenapanor 2mg A14011-2
Tenapanor 5mg A14011-5

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

Tenapanor acts as an inhibitor of the sodium-proton exchanger NHE3. This antiporter protein is found in the kidney and intestines, and normally acts to regulate the levels of sodium absorbed and secreted by the body.


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Publications citing Adooq Products
Tenapanor Citations (3)
  • Thammayon N,et al. Na+/H+ exchanger 3 inhibitor diminishes the amino-acid-enhanced transepithelial calcium transport across the rat duodenum, Amino Acids, 2017, Apr;49(4):725-734 27981415
  • Charoenphandhu N,et al. Na+/H+ exchanger 3 inhibitor diminishes hepcidin-enhanced duodenal calcium transport in hemizygous 汕-globin knockout thalassemic mice, Mol Cell Biochem, 2017, Mar;427(1-2):201-208 27995414
  • Jantarajit W,et al. CFTR-mediated anion secretion across intestinal epithelium-like Caco-2 monolayer under PTH stimulation is dependent on intermediate conductance K+ channels, Am J Physiol Cell Physiol, 2017, Jul 1;313(1):C118-C129 28490422

Chemical Information

Catalog Num A14011
Actions Inhibitor
M. Wt 1145.0614
Formula C50H66Cl4N8O10S2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1234423-95-0
Synonyms AZD1722, RDX5791
SMILES code CN1C[[email protected]](C2=CC(=CC(=C2C1)Cl)Cl)C3=CC(=CC=C3)S(=O)(=O)NCCOCCOCCNC(=O)NCCCCNC(=O)NCCOCCOCCNS(=O)(=O)C4=CC=CC(=C4)[[email protected]@H]5CN(CC6=C(C=C(C=C56)Cl)Cl)C
Chemical Name N,N'-(10,17,-dioxo-3,6,21,24-tetraoxa-9,11,16,18-tetraazahexacosane-1,26-diyl)bis([(4S)-6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl]benzenesulfonamide)

Biological Activity

Tenapanor acts as an inhibitor of the sodium-proton exchanger NHE3. This antiporter protein is found in the kidney and intestines, and normally acts to regulate the levels of sodium absorbed and secreted by the body.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 8.73 mL 43.67 mL 87.33mL
0.5 mM 1.75 mL 8.73 mL 17.47 mL
1 mM 0.87 mL 4.37 mL 8.73 mL
5 mM 0.17 mL 0.87 mL 1.75 mL

*The above data is based on the productmolecular weight 1145.0614. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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