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Publications citing Adooq Products
Tenapanor Citations (3)
- Thammayon N,et al. Na+/H+ exchanger 3 inhibitor diminishes the amino-acid-enhanced transepithelial calcium transport across the rat duodenum, Amino Acids, 2017, Apr;49(4):725-734 27981415
- Charoenphandhu N,et al. Na+/H+ exchanger 3 inhibitor diminishes hepcidin-enhanced duodenal calcium transport in hemizygous 汕-globin knockout thalassemic mice, Mol Cell Biochem, 2017, Mar;427(1-2):201-208 27995414
- Jantarajit W,et al. CFTR-mediated anion secretion across intestinal epithelium-like Caco-2 monolayer under PTH stimulation is dependent on intermediate conductance K+ channels, Am J Physiol Cell Physiol, 2017, Jul 1;313(1):C118-C129 28490422
Chemical Information
| Catalog Num | A14011 |
|---|---|
| Actions | Inhibitor |
| M. Wt | 1145.0614 |
| Formula | C50H66Cl4N8O10S2 |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 1234423-95-0 |
| Synonyms | AZD1722, RDX5791 |
| SMILES code | CN1C[[email protected]](C2=CC(=CC(=C2C1)Cl)Cl)C3=CC(=CC=C3)S(=O)(=O)NCCOCCOCCNC(=O)NCCCCNC(=O)NCCOCCOCCNS(=O)(=O)C4=CC=CC(=C4)[[email protected]@H]5CN(CC6=C(C=C(C=C56)Cl)Cl)C |
| Chemical Name | N,N'-(10,17,-dioxo-3,6,21,24-tetraoxa-9,11,16,18-tetraazahexacosane-1,26-diyl)bis([(4S)-6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl]benzenesulfonamide) |
Description |
Tenapanor acts as an inhibitor of the sodium-proton exchanger NHE3. This antiporter protein is found in the kidney and intestines, and normally acts to regulate the levels of sodium absorbed and secreted by the body. | |||||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 8.73 mL | 43.67 mL | 87.33mL |
| 0.5 mM | 1.75 mL | 8.73 mL | 17.47 mL |
| 1 mM | 0.87 mL | 4.37 mL | 8.73 mL |
| 5 mM | 0.17 mL | 0.87 mL | 1.75 mL |
*The above data is based on the productmolecular weight 1145.0614. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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