Total item
Cart Subtotal
$0.00 - Igase M,, .et al. Tenovin-6 induces the SIRT-independent cell growth suppression and blocks autophagy flux in canine hemangiosarcoma cell lines, Exp Cell Res, 2019, Dec 28:111810 PMID: 31891684
Biological Activity
Tenovin-6 is a analog of tenovin-1. Tenovin-6 inhibits the protein deacetylase activities of purified human SIRT1, SIRT2, and SIRT3 in vitro with IC50 values of 21, 10, and 67 uM, respectively.
Targets
| p53 | SIRT2 | SIRT1 | SIRT3 | |
| N/A | 10 μM | 21 μM | 67 μM |
| In vitro | DMSO | 98 mg/mL (215.55 mM) | |
| Water | 98 mg/mL heating (215.55 mM) | ||
| Ethanol | <1 mg/mL (<1 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 22 mL | 109.99 mL | 219.97 mL |
| 0.5 mM | 4.4 mL | 22 mL | 43.99 mL |
| 1 mM | 2.2 mL | 11 mL | 22 mL |
| 5 mM | 0.44 mL | 2.2 mL | 4.4 mL |
*The above data is based on the productmolecular weight 454.6. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A12305 |
|---|---|
| Actions | Activator |
| M. Wt | 454.6 |
| Formula | C25H34N4O2S |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 1011557-82-6 |
| Synonyms | Tenovin6, Tenovin 6 |
| SMILES | CC(C)(C)C1=CC=C(C=C1)C(=O)NC(=S)NC2=CC=C(C=C2)NC(=O)CCCCN(C)C |
Product Tags
Product Questions
Product Questions
No Questions
You may also be interested in the following product(s)
JNJ 26854165
JNJ-26854165 is one of p53-activating agents and synergizes with AraC or doxorubicin to induce p53-mediated apoptosis and may provide a nove…
WR 1065
WR 1065, a dephosphorylated metabolite of amifostine (Ethyol), can protect against the immediate and delayed effects of radiation exposure.
PRIMA-1
PRIMA-1 is a small molecule identified for its p53 reactivating effect.
RETRA hydrochloride
RETRA hydrochloride is an antitumor agent which inhibits tumor cell growth in a mutant p53- and p73-dependent manner in vitro and iin vivo.
Pifithrin-u
inhibits p53 binding to mitochondria by reducing its affinity for antiapoptotic proteins Bcl-2 and Bcl-XL.
NSC 146109 hydrochloride
NSC 146109 hydrochloride is a cell-permeable, genotype-selective antitumor agent that activates p53-dependent transcription.
Pifithrin-alpha
Pifithrin-a is a reversible inhibitor of p53-mediated apoptosis and p53-dependent gene transcription such as cyclin G, p21/waf1, and mdm2 ex…
p53 and MDM2 proteins-interaction-inhibitor racemic
p53 and MDM2 proteins-interaction-inhibitor racemic is an inhibitor of the interaction between p53 and MDM2 proteins.
Keywords:buy Tenovin-6 | Tenovin-6 Supplier | purchase | cost | manufacturer | order | distributor | buy 1011557-82-6| 1011557-82-6 Supplier | purchase 1011557-82-6 | 1011557-82-6 cost | 1011557-82-6 manufacturer | order 1011557-82-6 | 1011557-82-6 distributor
Adooq Quality Guarantee
We promise all products perform as described.