- Igase M,, .et al. Tenovin-6 induces the SIRT-independent cell growth suppression and blocks autophagy flux in canine hemangiosarcoma cell lines, Exp Cell Res, 2019, Dec 28:111810 PMID: 31891684
Biological Activity
Tenovin-6 is a analog of tenovin-1. Tenovin-6 inhibits the protein deacetylase activities of purified human SIRT1, SIRT2, and SIRT3 in vitro with IC50 values of 21, 10, and 67 uM, respectively.
Targets
p53 | SIRT2 | SIRT1 | SIRT3 | |
N/A | 10 μM | 21 μM | 67 μM |
In vitro | DMSO | 98 mg/mL (215.55 mM) | |
Water | 98 mg/mL heating (215.55 mM) | ||
Ethanol | <1 mg/mL (<1 mM) | ||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 22 mL | 109.99 mL | 219.97 mL |
0.5 mM | 4.4 mL | 22 mL | 43.99 mL |
1 mM | 2.2 mL | 11 mL | 22 mL |
5 mM | 0.44 mL | 2.2 mL | 4.4 mL |
*The above data is based on the productmolecular weight 454.6. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Catalog Num | A12305 |
---|---|
Actions | Activator |
M. Wt | 454.6 |
Formula | C25H34N4O2S |
Solubility | DMSO |
Purity | >98% |
Storage | at -20°C 3 years Powder |
CAS No. | 1011557-82-6 |
Synonyms | Tenovin6, Tenovin 6 |
SMILES | CC(C)(C)C1=CC=C(C=C1)C(=O)NC(=S)NC2=CC=C(C=C2)NC(=O)CCCCN(C)C |
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