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Tenovin-6

Tenovin-6

Name: Tenovin-6
Brand: Adooq Bioscience
SKU: A12305
Rating: 100 (1 reviews)

Catalog No.: A12305

p53 activator

Product Citations (1)

Tenovin-6 Chemical Structure

CAS NO. 1011557-82-6

Tenovin-6 is a analog of tenovin-1. Tenovin-6 inhibits the protein deacetylase activities of purified human SIRT1, SIRT2, and SIRT3 in vitro with IC50 values of 21, 10, and 67 uM, respectively.

Availability: In stock

Package	Price	Qty
5 mg	$70.00
10 mg	$90.00
25 mg	$160.00
10mM * 1mL in DMSO	$50.00
Custom Size	Get quote

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Products are for laboratory research use only. Not for human use. We do not sell to patients.

Adooq Products cited in reputable papers

Publications Citing Use of Adooq Tenovin-6

Igase M,, .et al. Tenovin-6 induces the SIRT-independent cell growth suppression and blocks autophagy flux in canine hemangiosarcoma cell lines, Exp Cell Res, 2019, Dec 28:111810 PMID: 31891684

Biological Activity

Tenovin-6 is a analog of tenovin-1. Tenovin-6 inhibits the protein deacetylase activities of purified human SIRT1, SIRT2, and SIRT3 in vitro with IC50 values of 21, 10, and 67 uM, respectively.

Targets

p53	SIRT2	SIRT1	SIRT3
N/A	10 μM	21 μM	67 μM

Solubility *

In vitro	DMSO	87 mg/mL (191.36 mM)
	Water	Warmed: 87 mg/mL (191.36 mM)
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	22 mL	109.99 mL	219.97 mL
0.5 mM	4.4 mL	22 mL	43.99 mL
1 mM	2.2 mL	11 mL	22 mL
5 mM	0.44 mL	2.2 mL	4.4 mL

*The above data is based on the productmolecular weight 454.6. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num	A12305
Actions	Activator
CAS No.	1011557-82-6
Formula	C25H34N4O2S
M. Wt	454.6
Solubility	DMSO
Purity	>98%
Synonyms	Tenovin6, Tenovin 6
SMILES	CC(C)(C)C1=CC=C(C=C1)C(=O)NC(=S)NC2=CC=C(C=C2)NC(=O)CCCCN(C)C
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.