Tetraethyl decane-1,10-diylbis(phosphonate)

Catalog No.: A83670
PROTAC Linkers
Tetraethyl decane-1,10-diylbis(phosphonate) is a phosphonate-based linker designed for use in the development of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the targeted degradation of specific proteins by linking E3 ligases with the protein of interest, enhancing cellular activity through the modulation of protein turnover. Its unique structure allows for effective construction of PROTACs, making it a valuable tool in drug discovery and research focused on targeted protein degradation.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionTetraethyl decane-1,10-diylbis(phosphonate) is a phosphonate-based linker designed for use in the development of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the targeted degradation of specific proteins by linking E3 ligases with the protein of interest, enhancing cellular activity through the modulation of protein turnover. Its unique structure allows for effective construction of PROTACs, making it a valuable tool in drug discovery and research focused on targeted protein degradation.
Product Information
Catalog NumA83670
FormulaC18H40O6P2
Molecular Weight414.45
CAS Number5943-62-4
SMILESO=P(OCC)(OCC)CCCCCCCCCCP(OCC)(OCC)=O
Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C1V1 = C2V2

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