Tezacaftor-d6 is a deuterium-labeled variant of Tezacaftor, a CFTR corrector designed to facilitate the proper trafficking of the F508del CFTR protein to the cell surface. Its primary mechanism involves correcting defects associated with cystic fibrosis (CF), particularly in patients homozygous for the CFTR Phe508del mutation. While Tezacaftor enhances CFTR protein presence, the co-administration with Ivacaftor, a CFTR potentiator, further improves channel activity, demonstrating significant therapeutic potential. This reagent is essential for studying CFTR modulation and the development of combination therapies for cystic fibrosis management.
Tezacaftor-d6 is a deuterium-labeled variant of Tezacaftor, a CFTR corrector designed to facilitate the proper trafficking of the F508del CFTR protein to the cell surface. Its primary mechanism involves correcting defects associated with cystic fibrosis (CF), particularly in patients homozygous for the CFTR Phe508del mutation. While Tezacaftor enhances CFTR protein presence, the co-administration with Ivacaftor, a CFTR potentiator, further improves channel activity, demonstrating significant therapeutic potential. This reagent is essential for studying CFTR modulation and the development of combination therapies for cystic fibrosis management.
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