TG101209

Catalog No.: A11180

JAK2 inhibitor

TG101209

TG101209 Chemical Structure

CAS NO. 936091-14-4

TG101209, a novel JAK2 inhibitor, has significant in vitro activity in multiple myeloma and displays preferential cytotoxicity for CD45+ myeloma cells.

Availability: In stock

Package Price Qty
5 mg
$70.00
10 mg
$120.00
50 mg
$400.00
100 mg
$700.00
10mM * 1mL in DMSO
$130.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

TG101209, a novel JAK2 inhibitor, has significant in vitro activity in multiple myeloma and displays preferential cytotoxicity for CD45+ myeloma cells.

Targets
JAK2 (Cell-free assay) RET (Cell-free assay) FLT3 (Cell-free assay) JAK3 (Cell-free assay)
6 nM17 nM25 nM169 nM
In vitro (25°C) DMSO 102 mg/mL (200.12 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 1% DMSO/30% polyethylene glycol/1% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.62 mL 98.1 mL 196.21 mL
0.5 mM 3.92 mL 19.62 mL 39.24 mL
1 mM 1.96 mL 9.81 mL 19.62 mL
5 mM 0.39 mL 1.96 mL 3.92 mL

*The above data is based on the productmolecular weight 509.67. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11180
Actions Inhibitor
M. Wt 509.67
Formula C26H35N7O2S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 936091-14-4
Synonyms TG-101209
SMILES CN1CCN(CC1)C2=CC=C(C=C2)NC3N=C(NC4=CC(=CC=C4)S(=O)(=O)NC(C)(C)C)C(C)=CN=3

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