TG101209

Name: TG101209
Brand: Adooq Bioscience
SKU: A11180
Rating: 100 (268 reviews)

Catalog No.: A11180

JAK2 inhibitor

TG101209 Chemical Structure

CAS NO. 936091-14-4

TG101209, a novel JAK2 inhibitor, has significant in vitro activity in multiple myeloma and displays preferential cytotoxicity for CD45+ myeloma cells.

Availability: In stock

Package	Price	Qty
5 mg	$70.00
10 mg	$120.00
50 mg	$270.00
100 mg	$485.00
10mM * 1mL in DMSO	$100.00
Custom Size	Get quote

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Biological Activity

TG101209, a novel JAK2 inhibitor, has significant in vitro activity in multiple myeloma and displays preferential cytotoxicity for CD45+ myeloma cells.

Targets

JAK2 (Cell-free assay)	RET (Cell-free assay)	FLT3 (Cell-free assay)	JAK3 (Cell-free assay)
6 nM	17 nM	25 nM	169 nM

Solubility *

In vitro (25°C)	DMSO	94 mg/mL (184.42 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	1% DMSO+30% polyethylene glycol+1% Tween 80	11 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	19.62 mL	98.1 mL	196.21 mL
0.5 mM	3.92 mL	19.62 mL	39.24 mL
1 mM	1.96 mL	9.81 mL	19.62 mL
5 mM	0.39 mL	1.96 mL	3.92 mL

*The above data is based on the productmolecular weight 509.67. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num	A11180
Actions	Inhibitor
CAS No.	936091-14-4
Formula	C26H35N7O2S
M. Wt	509.67
Purity	>98%
Synonyms	TG-101209
SMILES	CN1CCN(CC1)C2=CC=C(C=C2)NC3N=C(NC4=CC(=CC=C4)S(=O)(=O)NC(C)(C)C)C(C)=CN=3
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.