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- Anirudh Sattiraju, .et al. Spatial patterning and immunosuppression of glioblastoma immune contexture in hypoxic niches, bioRxiv, 2022, March 04
Biological Activity
TH-302 is a selectively targeting hypoxic regions of solid tumors hypoxia-activated prodrug.
Targets
| In vitro (25°C) | DMSO | 80 mg/mL (178.15 mM) | |
| Water | Warmed: 9 mg/mL (20.03 mM) | ||
| Ethanol | 80 mg/mL (178.15 mM) | ||
| In vivo | 30% propylene glycol, 5% Tween 80, 65% D5W | 28 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 22.27 mL | 111.36 mL | 222.72 mL |
| 0.5 mM | 4.45 mL | 22.27 mL | 44.54 mL |
| 1 mM | 2.23 mL | 11.14 mL | 22.27 mL |
| 5 mM | 0.45 mL | 2.23 mL | 4.45 mL |
*The above data is based on the productmolecular weight 449.0 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A11144 |
|---|---|
| CAS No. | 918633-87-1 |
| Formula | C9H16Br2N5O4P |
| M. Wt | 449.0 |
| Purity | >98% |
| Synonyms | TH302 |
| SMILES | CN1C(=CN=C1[N+](=O)[O-])COP(=O)(NCCBr)NCCBr |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
Datasheet
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