THAL-SNS-032

Catalog No.: A19088

CDK9 degrader PROTAC

THAL-SNS-032

THAL-SNS-032 Chemical Structure

CAS NO. 2139287-33-3

THAL-SNS-032 is a selective CDK9 degrader PROTAC consisting of a CDK-binding SNS-032 ligand linked to a thalidomide derivative that binds the E3 ubiquitin ligase Cereblon (CRBN).

Availability: In stock

Package Price Qty
5 mg
$315.00
10 mg
$543.00
50 mg
$1,610.00
100 mg
$3,220.00
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Biological Activity

THAL-SNS-032 is a selective CDK9 degrader PROTAC consisting of a CDK-binding SNS-032 ligand linked to a thalidomide derivative that binds the E3 ubiquitin ligase Cereblon (CRBN).
In vitro DMSO 89 mg/mL (102.41 mM)
Water Insoluble
Ethanol 27 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 11.51 mL 57.54 mL 115.07 mL
0.5 mM 2.3 mL 11.51 mL 23.01 mL
1 mM 1.15 mL 5.75 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL

*The above data is based on the productmolecular weight 869.02. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A19088
Actions Degrader
CAS No. 2139287-33-3
Formula C40H52N8O10S2
M. Wt 869.02
Solubility DMSO
Purity >98%
SMILES O=C(NCCOCCOCCOCCNC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O)CN4CCC(C(NC5=NC=C(SCC6=NC=C(C(C)(C)C)O6)S5)=O)CC4
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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