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Thalidomide-5-(C6-amine)

Thalidomide Analogue

Thalidomide-5-(C6-amine) is a thalidomide analogue functioning as a PROTAC building block, featuring an E3 ligase ligand with a terminal amine group. This amine group facilitates conjugation reactions with NHS ester groups or carboxylic acids in the presence of coupling agents such as EDC or HATU. Thalidomide-5-(C6-amine) is valuable in the development of bifunctional degraders, supporting research in targeted protein degradation and therapeutic interventions.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Degrader
CAS Number	1950635-17-2
Applications	Thalidomide Analogue
Formula	C₂₀H₂₄N₄O₅
Molecular Weight	400.43
SMILES	NCCCCCCNC(C1=CC=C2C(N(C(C2=C1)=O)C3CCC(NC3=O)=O)=O)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.