Thalidomide-O-amido-C6-NH2

Catalog No.: A31557
E3 Ligase Ligand-Linker Conjugates
Thalidomide-O-amido-C6-NH2 serves as an E3 ligase ligand-linker conjugate, featuring a thalidomide-based cereblon ligand with an integrated linker. This compound is utilized in the synthesis of PROTACs (proteolysis-targeting chimeras), facilitating targeted protein degradation pathways. Its unique structure allows for selective degradation of specific proteins, making it valuable in cancer research and other therapeutic applications.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionThalidomide-O-amido-C6-NH2 serves as an E3 ligase ligand-linker conjugate, featuring a thalidomide-based cereblon ligand with an integrated linker. This compound is utilized in the synthesis of PROTACs (proteolysis-targeting chimeras), facilitating targeted protein degradation pathways. Its unique structure allows for selective degradation of specific proteins, making it valuable in cancer research and other therapeutic applications.
Product Information
Catalog NumA31557
FormulaC21H26N4O6
Molecular Weight430.45
CAS Number1950635-13-8
SMILESO=C(NCCCCCCN)COC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O
SynonymsCereblon Ligand-Linker Conjugates 11; E3 Ligase Ligand-Linker Conjugates 25
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This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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