Thalidomide-O-amido-PEG1-(C1-PEG)2-C2-NH2

Catalog No.: A31515
E3 Ligase Ligand-Linker Conjugates
Thalidomide-O-amido-PEG1-(C1-PEG)2-C2-NH2 is a synthesized E3 ligase ligand-linker conjugate targeting cereblon, a key component in the ubiquitin-proteasome pathway. This compound is designed to facilitate targeted protein degradation through PROTAC technology, enabling researchers to manipulate cellular protein levels with high specificity. Its unique linker structure enhances the conjugate’s stability and efficacy in various biological applications, making it a valuable tool for studying protein regulation and therapeutic interventions.
Grouped product items
Size Stock
5mg
10mg
50mg
Bulk Size
Bulk Discount
Free Delivery on orders over $500
Research use only. We do not sell to patients.

Loading distributor info...

Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionThalidomide-O-amido-PEG1-(C1-PEG)2-C2-NH2 is a synthesized E3 ligase ligand-linker conjugate targeting cereblon, a key component in the ubiquitin-proteasome pathway. This compound is designed to facilitate targeted protein degradation through PROTAC technology, enabling researchers to manipulate cellular protein levels with high specificity. Its unique linker structure enhances the conjugate’s stability and efficacy in various biological applications, making it a valuable tool for studying protein regulation and therapeutic interventions.
Product Information
Catalog NumA31515
FormulaC25H34N4O9
Molecular Weight534.56
CAS Number2435572-48-6
SMILESO=C(NCCOCCCOCCCOCCN)COC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O
SynonymsCereblon Ligand-Linker Conjugates 12; E3 Ligase Ligand-Linker Conjugates 23
Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass

    Concentration

    Volume

    Molecular Weight

Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C1V1 = C2V2

  • C1

    V1

    C2

    V2