Thalidomide-O-amido-PEG4-azide is a PEG-based linker designed for the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound possesses an azide group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. Additionally, it can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN functionalized compounds. This makes Thalidomide-O-amido-PEG4-azide a versatile tool in targeted protein degradation applications and chemical biology research.
Thalidomide-O-amido-PEG4-azide is a PEG-based linker designed for the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound possesses an azide group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. Additionally, it can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN functionalized compounds. This makes Thalidomide-O-amido-PEG4-azide a versatile tool in targeted protein degradation applications and chemical biology research.
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